Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells
Objective. Glucocorticoids are important stress-responsive regulators of insulin-dependent metabolic processes realized through specific changes in genome function. The aim of this study was to investigate the impact of cortisol on insulin receptor and related genes expression in HEK293 cells upon i...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-01-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2024-0001 |
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| author | Minchenko Dmytro O. Khita Olena O. Viletska Yuliia M. Sliusar Myroslava Y. Rudnytska Olha V. Kozynkevych Halyna E. Bezrodnyi Borys H. Khikhlo Yevgen P. Minchenko Oleksandr H. |
| author_facet | Minchenko Dmytro O. Khita Olena O. Viletska Yuliia M. Sliusar Myroslava Y. Rudnytska Olha V. Kozynkevych Halyna E. Bezrodnyi Borys H. Khikhlo Yevgen P. Minchenko Oleksandr H. |
| author_sort | Minchenko Dmytro O. |
| collection | DOAJ |
| description | Objective. Glucocorticoids are important stress-responsive regulators of insulin-dependent metabolic processes realized through specific changes in genome function. The aim of this study was to investigate the impact of cortisol on insulin receptor and related genes expression in HEK293 cells upon induction the endoplasmic reticulum (ER) stress by tunicamycin and hypoxia. |
| format | Article |
| id | doaj-art-b609e490dc3c40e88c18f131f83ee809 |
| institution | OA Journals |
| issn | 1336-0329 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj-art-b609e490dc3c40e88c18f131f83ee8092025-08-20T02:33:31ZengSciendoEndocrine Regulations1336-03292024-01-0158111010.2478/enr-2024-0001Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cellsMinchenko Dmytro O.0Khita Olena O.1Viletska Yuliia M.2Sliusar Myroslava Y.3Rudnytska Olha V.4Kozynkevych Halyna E.5Bezrodnyi Borys H.6Khikhlo Yevgen P.7Minchenko Oleksandr H.8Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, UkraineDepartments of Pediatrics No.1 and Surgery, National Bohomolets Medical University, Kyiv, UkraineDepartments of Pediatrics No.1 and Surgery, National Bohomolets Medical University, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, UkraineObjective. Glucocorticoids are important stress-responsive regulators of insulin-dependent metabolic processes realized through specific changes in genome function. The aim of this study was to investigate the impact of cortisol on insulin receptor and related genes expression in HEK293 cells upon induction the endoplasmic reticulum (ER) stress by tunicamycin and hypoxia.https://doi.org/10.2478/enr-2024-0001cortisoltunicamycinhypoxiaxbp1sinsulin receptorirs2insig2dnajb9hek293 |
| spellingShingle | Minchenko Dmytro O. Khita Olena O. Viletska Yuliia M. Sliusar Myroslava Y. Rudnytska Olha V. Kozynkevych Halyna E. Bezrodnyi Borys H. Khikhlo Yevgen P. Minchenko Oleksandr H. Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells Endocrine Regulations cortisol tunicamycin hypoxia xbp1s insulin receptor irs2 insig2 dnajb9 hek293 |
| title | Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells |
| title_full | Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells |
| title_fullStr | Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells |
| title_full_unstemmed | Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells |
| title_short | Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells |
| title_sort | cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in hek293 cells |
| topic | cortisol tunicamycin hypoxia xbp1s insulin receptor irs2 insig2 dnajb9 hek293 |
| url | https://doi.org/10.2478/enr-2024-0001 |
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