Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection
Monoclonal gammopathy reflects a serological disorder suggesting a plasma cell dyscrasia or a B-cell abnormality. However, it may occasionally be encountered as a transient manifestation in the course of several diseases including infections. This is the first reported case of a transient monoclonal...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/607104 |
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| author | Dimitrios Stoimenis Christina Spyridonidou Nikos Papaioannou |
| author_facet | Dimitrios Stoimenis Christina Spyridonidou Nikos Papaioannou |
| author_sort | Dimitrios Stoimenis |
| collection | DOAJ |
| description | Monoclonal gammopathy reflects a serological disorder suggesting a plasma cell dyscrasia or a B-cell abnormality. However, it may occasionally be encountered as a transient manifestation in the course of several diseases including infections. This is the first reported case of a transient monoclonal gammopathy IgG lambda light chain associated with a Staphylococcus aureus infection that was complicated with renal abscess and vertebral spondylodiscitis in a previously healthy 68-year-old male. We observed a complete resolution of the gammopathy within three months of medical treatment before the entire restoration of all clinical and laboratory findings. Many invasive and cost-intensive diagnostic procedures had preceded the exclusion of a malignancy. The clinical significance and the exact pathogenesis of transient monoclonality are poorly understood and remain a matter of speculation. |
| format | Article |
| id | doaj-art-b60435e8dbd64f8fb4fdc83936a527c8 |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b60435e8dbd64f8fb4fdc83936a527c82025-08-20T02:23:23ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/607104607104Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus InfectionDimitrios Stoimenis0Christina Spyridonidou1Nikos Papaioannou21st Department of Internal Medicine, “Georgios Papanikolaou” General Hospital, Exochi, 570 10 Thessaloniki, Greece1st Department of Internal Medicine, “Georgios Papanikolaou” General Hospital, Exochi, 570 10 Thessaloniki, Greece1st Department of Internal Medicine, “Georgios Papanikolaou” General Hospital, Exochi, 570 10 Thessaloniki, GreeceMonoclonal gammopathy reflects a serological disorder suggesting a plasma cell dyscrasia or a B-cell abnormality. However, it may occasionally be encountered as a transient manifestation in the course of several diseases including infections. This is the first reported case of a transient monoclonal gammopathy IgG lambda light chain associated with a Staphylococcus aureus infection that was complicated with renal abscess and vertebral spondylodiscitis in a previously healthy 68-year-old male. We observed a complete resolution of the gammopathy within three months of medical treatment before the entire restoration of all clinical and laboratory findings. Many invasive and cost-intensive diagnostic procedures had preceded the exclusion of a malignancy. The clinical significance and the exact pathogenesis of transient monoclonality are poorly understood and remain a matter of speculation.http://dx.doi.org/10.1155/2012/607104 |
| spellingShingle | Dimitrios Stoimenis Christina Spyridonidou Nikos Papaioannou Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection Case Reports in Medicine |
| title | Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection |
| title_full | Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection |
| title_fullStr | Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection |
| title_full_unstemmed | Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection |
| title_short | Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection |
| title_sort | transient monoclonal gammopathy induced by disseminated staphylococcus aureus infection |
| url | http://dx.doi.org/10.1155/2012/607104 |
| work_keys_str_mv | AT dimitriosstoimenis transientmonoclonalgammopathyinducedbydisseminatedstaphylococcusaureusinfection AT christinaspyridonidou transientmonoclonalgammopathyinducedbydisseminatedstaphylococcusaureusinfection AT nikospapaioannou transientmonoclonalgammopathyinducedbydisseminatedstaphylococcusaureusinfection |