Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy
Objectives. To compare dexmedetomidine versus magnesium during laparoscopic colectomy. Patients and Methods. 51 patients were randomly allocated into 3 groups: group C (control) received saline infusion, group D dexmedetomidine 1 g/kg and then 0.4 g/kg/hr, and group M MgSO4 2 g and then 15 g/kg/min....
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/7172920 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547597642891264 |
|---|---|
| author | Pierre Zarif Ahmed Abdelaal Ahmed Mahmoud Mohamed Mohamed Abdelhaq Hany M. S. Mikhail Ahmed Farag |
| author_facet | Pierre Zarif Ahmed Abdelaal Ahmed Mahmoud Mohamed Mohamed Abdelhaq Hany M. S. Mikhail Ahmed Farag |
| author_sort | Pierre Zarif |
| collection | DOAJ |
| description | Objectives. To compare dexmedetomidine versus magnesium during laparoscopic colectomy. Patients and Methods. 51 patients were randomly allocated into 3 groups: group C (control) received saline infusion, group D dexmedetomidine 1 g/kg and then 0.4 g/kg/hr, and group M MgSO4 2 g and then 15 g/kg/min. Intraoperative hemodynamics were measured before and 1 min after intubation (T1 and T2), before and 5 min after peritoneal insufflation (T3 and T4), before and 5 min after 30° Trendelenburg position (T5 and T6), 5 min after resuming flat position (T7), 5 min after peritoneal deflations (T8), after extubation (T9), and at time of admission to PACU (T10). Recovery time and degree of sedation were assessed. Results. HR and MAP were significantly higher in T2, T4, and T6 compared to T1, T3, and T5, respectively, in all groups with lower measurements in groups D and M compared to group C. Mean of collective measurements was significantly higher in group C. Recovery time and sedation score were significantly higher in groups D and M. Time to Aldrete score of ≥9 was significantly longer in groups D and M. Conclusion. Both drugs ameliorate the pressor responses during LC with a nonsignificant difference. This study is registered with PACTR201602001481308. |
| format | Article |
| id | doaj-art-b6042dd91c8b4c58b55eb8280e3e5c72 |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-b6042dd91c8b4c58b55eb8280e3e5c722025-02-03T06:44:21ZengWileyAnesthesiology Research and Practice1687-69621687-69702016-01-01201610.1155/2016/71729207172920Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic ColectomyPierre Zarif0Ahmed Abdelaal Ahmed Mahmoud1Mohamed Mohamed Abdelhaq2Hany M. S. Mikhail3Ahmed Farag4Department of Anesthesiology, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of Anesthesiology, Faculty of Medicine, Beni-Suef University, Beni Suef, EgyptDepartment of Anesthesiology, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of General Surgery, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of General Surgery, Faculty of Medicine, Cairo University, Giza, EgyptObjectives. To compare dexmedetomidine versus magnesium during laparoscopic colectomy. Patients and Methods. 51 patients were randomly allocated into 3 groups: group C (control) received saline infusion, group D dexmedetomidine 1 g/kg and then 0.4 g/kg/hr, and group M MgSO4 2 g and then 15 g/kg/min. Intraoperative hemodynamics were measured before and 1 min after intubation (T1 and T2), before and 5 min after peritoneal insufflation (T3 and T4), before and 5 min after 30° Trendelenburg position (T5 and T6), 5 min after resuming flat position (T7), 5 min after peritoneal deflations (T8), after extubation (T9), and at time of admission to PACU (T10). Recovery time and degree of sedation were assessed. Results. HR and MAP were significantly higher in T2, T4, and T6 compared to T1, T3, and T5, respectively, in all groups with lower measurements in groups D and M compared to group C. Mean of collective measurements was significantly higher in group C. Recovery time and sedation score were significantly higher in groups D and M. Time to Aldrete score of ≥9 was significantly longer in groups D and M. Conclusion. Both drugs ameliorate the pressor responses during LC with a nonsignificant difference. This study is registered with PACTR201602001481308.http://dx.doi.org/10.1155/2016/7172920 |
| spellingShingle | Pierre Zarif Ahmed Abdelaal Ahmed Mahmoud Mohamed Mohamed Abdelhaq Hany M. S. Mikhail Ahmed Farag Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy Anesthesiology Research and Practice |
| title | Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy |
| title_full | Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy |
| title_fullStr | Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy |
| title_full_unstemmed | Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy |
| title_short | Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy |
| title_sort | dexmedetomidine versus magnesium sulfate as adjunct during anesthesia for laparoscopic colectomy |
| url | http://dx.doi.org/10.1155/2016/7172920 |
| work_keys_str_mv | AT pierrezarif dexmedetomidineversusmagnesiumsulfateasadjunctduringanesthesiaforlaparoscopiccolectomy AT ahmedabdelaalahmedmahmoud dexmedetomidineversusmagnesiumsulfateasadjunctduringanesthesiaforlaparoscopiccolectomy AT mohamedmohamedabdelhaq dexmedetomidineversusmagnesiumsulfateasadjunctduringanesthesiaforlaparoscopiccolectomy AT hanymsmikhail dexmedetomidineversusmagnesiumsulfateasadjunctduringanesthesiaforlaparoscopiccolectomy AT ahmedfarag dexmedetomidineversusmagnesiumsulfateasadjunctduringanesthesiaforlaparoscopiccolectomy |