Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity
In this work partially and completely N-oxidized N-vinylpyrrolidone-2-methyl-5-vinylpyridine copolymers were synthesized. The influence of рН on the reaction course was studied. For obtaining the copolymer N-oxidized by 100% it is necessary to carry out the reaction in an acetate buffer solution. If...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2015-10-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/256 |
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| author | E. V. Vorfolomeeva S. A. Kedik A. V. Panov D. V. Vasilyeva |
| author_facet | E. V. Vorfolomeeva S. A. Kedik A. V. Panov D. V. Vasilyeva |
| author_sort | E. V. Vorfolomeeva |
| collection | DOAJ |
| description | In this work partially and completely N-oxidized N-vinylpyrrolidone-2-methyl-5-vinylpyridine copolymers were synthesized. The influence of рН on the reaction course was studied. For obtaining the copolymer N-oxidized by 100% it is necessary to carry out the reaction in an acetate buffer solution. If obtaining the partially N-oxidized copolymer, a citrate buffer solution should be used, which allows carrying out the reaction at a smaller speed and as a result enables to stop the reaction in the necessary range. The dependence of biological activity on the extent of N-oxidation was studied. An immunostimulating effect of N-vinylpyrrolidone-2-methyl-5-vinylpyridine N-oxide copolymers with various extent of N-oxidation was revealed in vivo with an anthrax vaccine. |
| format | Article |
| id | doaj-art-b6034858a6c54755a896c45b8a93243c |
| institution | DOAJ |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-b6034858a6c54755a896c45b8a93243c2025-08-20T03:00:01ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752015-10-011053338250Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activityE. V. Vorfolomeeva0S. A. Kedik1A. V. Panov2D. V. Vasilyeva3M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571In this work partially and completely N-oxidized N-vinylpyrrolidone-2-methyl-5-vinylpyridine copolymers were synthesized. The influence of рН on the reaction course was studied. For obtaining the copolymer N-oxidized by 100% it is necessary to carry out the reaction in an acetate buffer solution. If obtaining the partially N-oxidized copolymer, a citrate buffer solution should be used, which allows carrying out the reaction at a smaller speed and as a result enables to stop the reaction in the necessary range. The dependence of biological activity on the extent of N-oxidation was studied. An immunostimulating effect of N-vinylpyrrolidone-2-methyl-5-vinylpyridine N-oxide copolymers with various extent of N-oxidation was revealed in vivo with an anthrax vaccine.https://www.finechem-mirea.ru/jour/article/view/256n-vinylpirrolidone, 2-methyl-5-vinylpyridine, n-oxide, immunoadjuvant activity. |
| spellingShingle | E. V. Vorfolomeeva S. A. Kedik A. V. Panov D. V. Vasilyeva Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity Тонкие химические технологии n-vinylpirrolidone, 2-methyl-5-vinylpyridine, n-oxide, immunoadjuvant activity. |
| title | Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity |
| title_full | Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity |
| title_fullStr | Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity |
| title_full_unstemmed | Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity |
| title_short | Preparing water-soluble n-vinylpyrrolidone-2-methyl-5-vinylpyridine n-oxide copolymers and research on their immunoadjuvant activity |
| title_sort | preparing water soluble n vinylpyrrolidone 2 methyl 5 vinylpyridine n oxide copolymers and research on their immunoadjuvant activity |
| topic | n-vinylpirrolidone, 2-methyl-5-vinylpyridine, n-oxide, immunoadjuvant activity. |
| url | https://www.finechem-mirea.ru/jour/article/view/256 |
| work_keys_str_mv | AT evvorfolomeeva preparingwatersolublenvinylpyrrolidone2methyl5vinylpyridinenoxidecopolymersandresearchontheirimmunoadjuvantactivity AT sakedik preparingwatersolublenvinylpyrrolidone2methyl5vinylpyridinenoxidecopolymersandresearchontheirimmunoadjuvantactivity AT avpanov preparingwatersolublenvinylpyrrolidone2methyl5vinylpyridinenoxidecopolymersandresearchontheirimmunoadjuvantactivity AT dvvasilyeva preparingwatersolublenvinylpyrrolidone2methyl5vinylpyridinenoxidecopolymersandresearchontheirimmunoadjuvantactivity |