Limbal Epithelial Stem Cells in Corneal Regeneration
The cornea is the transparent and outer most part of the eye, which is responsible for clear vision. The homeostasis of corneal epithelium is maintained by stem cells (SCs) located at the limbus, which is a transitional zone between cornea and conjunctiva. Due to some conditions limbal stem cells (L...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-07-01
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| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.7869/djo.2013.9 |
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| author | Shweta Sharma M. Vanathi Sujata Mohanty Radhika Tandon |
| author_facet | Shweta Sharma M. Vanathi Sujata Mohanty Radhika Tandon |
| author_sort | Shweta Sharma |
| collection | DOAJ |
| description | The cornea is the transparent and outer most part of the eye, which is responsible for clear vision. The homeostasis of corneal epithelium is maintained by stem cells (SCs) located at the limbus, which is a transitional zone between cornea and conjunctiva. Due to some conditions limbal stem cells (LSCs) can be destroyed or lost and this can cause limbal stem cell deficiency (LSCD). Conventional non-surgical management and corneal transplants are not enough to treat LSCD. Recent advances in tissue engineering have made possible to rejuvenate the LSC deficit ocular surface with ex-vivo cultivated limbal epithelium and this is possible to achieve from a significantly small limbal biopsy.
In spite of all progress made in this field, it is still questionable to identify LSCs based on the biomarkers. This review article will focus on the biology of LSCs and their emerging trend in the field of regenerative medicine. Apart from that this article will also highlight different culture techniques to cultivate LSCs and novel biofunctional scaffolds. |
| format | Article |
| id | doaj-art-b602ef196ec84fd8be044c50d45e78fc |
| institution | Kabale University |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2013-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-b602ef196ec84fd8be044c50d45e78fc2025-08-20T03:52:29ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842013-07-01241435010.7869/djo.2013.9Limbal Epithelial Stem Cells in Corneal RegenerationShweta SharmaM. VanathiSujata MohantyRadhika TandonThe cornea is the transparent and outer most part of the eye, which is responsible for clear vision. The homeostasis of corneal epithelium is maintained by stem cells (SCs) located at the limbus, which is a transitional zone between cornea and conjunctiva. Due to some conditions limbal stem cells (LSCs) can be destroyed or lost and this can cause limbal stem cell deficiency (LSCD). Conventional non-surgical management and corneal transplants are not enough to treat LSCD. Recent advances in tissue engineering have made possible to rejuvenate the LSC deficit ocular surface with ex-vivo cultivated limbal epithelium and this is possible to achieve from a significantly small limbal biopsy. In spite of all progress made in this field, it is still questionable to identify LSCs based on the biomarkers. This review article will focus on the biology of LSCs and their emerging trend in the field of regenerative medicine. Apart from that this article will also highlight different culture techniques to cultivate LSCs and novel biofunctional scaffolds.https://journals.lww.com/10.7869/djo.2013.9cornealimbal stem cellslimbal stem cells deficiencylimbal stem cells transplantationbiopolymer |
| spellingShingle | Shweta Sharma M. Vanathi Sujata Mohanty Radhika Tandon Limbal Epithelial Stem Cells in Corneal Regeneration Delhi Journal of Ophthalmology cornea limbal stem cells limbal stem cells deficiency limbal stem cells transplantation biopolymer |
| title | Limbal Epithelial Stem Cells in Corneal Regeneration |
| title_full | Limbal Epithelial Stem Cells in Corneal Regeneration |
| title_fullStr | Limbal Epithelial Stem Cells in Corneal Regeneration |
| title_full_unstemmed | Limbal Epithelial Stem Cells in Corneal Regeneration |
| title_short | Limbal Epithelial Stem Cells in Corneal Regeneration |
| title_sort | limbal epithelial stem cells in corneal regeneration |
| topic | cornea limbal stem cells limbal stem cells deficiency limbal stem cells transplantation biopolymer |
| url | https://journals.lww.com/10.7869/djo.2013.9 |
| work_keys_str_mv | AT shwetasharma limbalepithelialstemcellsincornealregeneration AT mvanathi limbalepithelialstemcellsincornealregeneration AT sujatamohanty limbalepithelialstemcellsincornealregeneration AT radhikatandon limbalepithelialstemcellsincornealregeneration |