The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress
The <i>Osgin</i> gene family consists of two members, <i>Osgin1</i> and <i>Osgin2</i>, involved in the cellular oxidative stress response. While many members of this essential cellular pathway have been extensively characterized, the <i>Osgin</i> gene...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/3/409 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850090346035281920 |
|---|---|
| author | Grace Hussey Marcus Royster Nivedha Vaidy Michael Culkin Margaret S. Saha |
| author_facet | Grace Hussey Marcus Royster Nivedha Vaidy Michael Culkin Margaret S. Saha |
| author_sort | Grace Hussey |
| collection | DOAJ |
| description | The <i>Osgin</i> gene family consists of two members, <i>Osgin1</i> and <i>Osgin2</i>, involved in the cellular oxidative stress response. While many members of this essential cellular pathway have been extensively characterized, the <i>Osgin</i> gene family, despite its broad phylogenetic distribution, has received far less attention. Here, we review published articles and open-source databases to synthesize the current research on the evolutionary history, structure, biochemical and physiological functions, expression patterns, and role in disease of the <i>Osgin</i> gene family. Although <i>Osgin</i> displays broad spatiotemporal expression during development and adulthood, there is ambiguity regarding the cellular functions of the OSGIN proteins. A recent study identified OSGIN-1 as a flavin-dependent monooxygenase, but the biochemical role of OSGIN-2 has not yet been defined. Moreover, while the <i>Osgin</i> genes are implicated as mediators of cell proliferation, apoptosis, and autophagy, these functions have not been connected to the enzymatic classification of OSGIN. Misregulation of <i>Osgin</i> expression has long been associated with various disease states, yet recent analyses highlight the mechanistic role of OSGIN in pathogenesis and disease progression, underscoring the therapeutic potential of targeting OSGIN. In light of these findings, we suggest further avenues of research to advance our understanding of this essential, yet underexplored, gene family. |
| format | Article |
| id | doaj-art-b601c2ee39fd46e5b771f121b82be861 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-b601c2ee39fd46e5b771f121b82be8612025-08-20T02:42:35ZengMDPI AGBiomolecules2218-273X2025-03-0115340910.3390/biom15030409The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative StressGrace Hussey0Marcus Royster1Nivedha Vaidy2Michael Culkin3Margaret S. Saha4Biology Department, William & Mary, Williamsburg, VA 23185, USABiology Department, William & Mary, Williamsburg, VA 23185, USABiology Department, William & Mary, Williamsburg, VA 23185, USABiology Department, William & Mary, Williamsburg, VA 23185, USABiology Department, William & Mary, Williamsburg, VA 23185, USAThe <i>Osgin</i> gene family consists of two members, <i>Osgin1</i> and <i>Osgin2</i>, involved in the cellular oxidative stress response. While many members of this essential cellular pathway have been extensively characterized, the <i>Osgin</i> gene family, despite its broad phylogenetic distribution, has received far less attention. Here, we review published articles and open-source databases to synthesize the current research on the evolutionary history, structure, biochemical and physiological functions, expression patterns, and role in disease of the <i>Osgin</i> gene family. Although <i>Osgin</i> displays broad spatiotemporal expression during development and adulthood, there is ambiguity regarding the cellular functions of the OSGIN proteins. A recent study identified OSGIN-1 as a flavin-dependent monooxygenase, but the biochemical role of OSGIN-2 has not yet been defined. Moreover, while the <i>Osgin</i> genes are implicated as mediators of cell proliferation, apoptosis, and autophagy, these functions have not been connected to the enzymatic classification of OSGIN. Misregulation of <i>Osgin</i> expression has long been associated with various disease states, yet recent analyses highlight the mechanistic role of OSGIN in pathogenesis and disease progression, underscoring the therapeutic potential of targeting OSGIN. In light of these findings, we suggest further avenues of research to advance our understanding of this essential, yet underexplored, gene family.https://www.mdpi.com/2218-273X/15/3/409<i>Osgin1</i><i>Osgin2</i>oxidative stressflavin-dependent monooxygenasetumorigenesis |
| spellingShingle | Grace Hussey Marcus Royster Nivedha Vaidy Michael Culkin Margaret S. Saha The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress Biomolecules <i>Osgin1</i> <i>Osgin2</i> oxidative stress flavin-dependent monooxygenase tumorigenesis |
| title | The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress |
| title_full | The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress |
| title_fullStr | The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress |
| title_full_unstemmed | The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress |
| title_short | The <i>Osgin</i> Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress |
| title_sort | i osgin i gene family underexplored yet essential mediators of oxidative stress |
| topic | <i>Osgin1</i> <i>Osgin2</i> oxidative stress flavin-dependent monooxygenase tumorigenesis |
| url | https://www.mdpi.com/2218-273X/15/3/409 |
| work_keys_str_mv | AT gracehussey theiosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT marcusroyster theiosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT nivedhavaidy theiosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT michaelculkin theiosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT margaretssaha theiosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT gracehussey iosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT marcusroyster iosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT nivedhavaidy iosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT michaelculkin iosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress AT margaretssaha iosginigenefamilyunderexploredyetessentialmediatorsofoxidativestress |