Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Abstract Background Until recently, severe fever with thrombocytopenia syndrome (SFTS)-related disseminated intravascular coagulation (DIC) had not been elucidated. This study aimed to explore the clinical characteristics and outcomes of DIC in patients with SFTS. Methods Patients diagnosed with SFT...
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2025-04-01
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| Online Access: | https://doi.org/10.1186/s12879-025-10900-y |
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| author | Zhongwei Zhang Xue Hu Qian Du Pingzheng Mo Xiaoping Chen Mingqi Luo Qunqun Jiang Liping Deng Yong Xiong |
| author_facet | Zhongwei Zhang Xue Hu Qian Du Pingzheng Mo Xiaoping Chen Mingqi Luo Qunqun Jiang Liping Deng Yong Xiong |
| author_sort | Zhongwei Zhang |
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| description | Abstract Background Until recently, severe fever with thrombocytopenia syndrome (SFTS)-related disseminated intravascular coagulation (DIC) had not been elucidated. This study aimed to explore the clinical characteristics and outcomes of DIC in patients with SFTS. Methods Patients diagnosed with SFTS who were admitted to Zhongnan Hospital of Wuhan University from August 2016 to October 2023 were included. Patients’ demographics and clinical data were collected. According to the presence of DIC, they were assigned into the DIC and non-DIC groups. Independent risk factors for prognosis were identified by univariate and multivariate logistic regression analyses. Results A total of 246 consecutive patients diagnosed with SFTS were enrolled, including 216 (87.8%) patients in the non-DIC group and 30 (12.2%) patients in the DIC group. ALT, AST, ALP, GGT, LDH, creatinine, cystatin-C, amylase, lipase, CK, CK-MB, troponin I, BNP, PT, PTA, APTT, TT, FDP, D-dimer, CRP, procalcitonin, IL-6, SAA, ESR, ferritin levels, and viral load were significantly higher in patients with DIC. The cumulative survival rate of patients with DIC was significantly lower than that of patients without DIC. Furthermore, it is demonstrated that the presence of DIC was an independent risk factor for in-hospital mortality of patients with SFTS. Conclusion DIC is a potential complication and is associated with high mortality in patients with SFTS. Early recognition and timely management of this serious complication are important for patients with SFTS. |
| format | Article |
| id | doaj-art-b601bcba3609491f90650f3ff3c1c29d |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj-art-b601bcba3609491f90650f3ff3c1c29d2025-08-20T02:12:03ZengBMCBMC Infectious Diseases1471-23342025-04-012511810.1186/s12879-025-10900-yClinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndromeZhongwei Zhang0Xue Hu1Qian Du2Pingzheng Mo3Xiaoping Chen4Mingqi Luo5Qunqun Jiang6Liping Deng7Yong Xiong8Department of Infectious Disease, Zhongnan Hospital of Wuhan UniversityDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and TechnologyDepartment of Infectious Disease, Zhongnan Hospital of Wuhan UniversityDepartment of Infectious Disease, Zhongnan Hospital of Wuhan UniversityDepartment of Infectious Disease, Zhongnan Hospital of Wuhan UniversityDepartment of Infectious Disease, Zhongnan Hospital of Wuhan UniversityDepartment of Infectious Disease, Zhongnan Hospital of Wuhan UniversityDepartment of Infectious Disease, Zhongnan Hospital of Wuhan UniversityDepartment of Infectious Disease, Zhongnan Hospital of Wuhan UniversityAbstract Background Until recently, severe fever with thrombocytopenia syndrome (SFTS)-related disseminated intravascular coagulation (DIC) had not been elucidated. This study aimed to explore the clinical characteristics and outcomes of DIC in patients with SFTS. Methods Patients diagnosed with SFTS who were admitted to Zhongnan Hospital of Wuhan University from August 2016 to October 2023 were included. Patients’ demographics and clinical data were collected. According to the presence of DIC, they were assigned into the DIC and non-DIC groups. Independent risk factors for prognosis were identified by univariate and multivariate logistic regression analyses. Results A total of 246 consecutive patients diagnosed with SFTS were enrolled, including 216 (87.8%) patients in the non-DIC group and 30 (12.2%) patients in the DIC group. ALT, AST, ALP, GGT, LDH, creatinine, cystatin-C, amylase, lipase, CK, CK-MB, troponin I, BNP, PT, PTA, APTT, TT, FDP, D-dimer, CRP, procalcitonin, IL-6, SAA, ESR, ferritin levels, and viral load were significantly higher in patients with DIC. The cumulative survival rate of patients with DIC was significantly lower than that of patients without DIC. Furthermore, it is demonstrated that the presence of DIC was an independent risk factor for in-hospital mortality of patients with SFTS. Conclusion DIC is a potential complication and is associated with high mortality in patients with SFTS. Early recognition and timely management of this serious complication are important for patients with SFTS.https://doi.org/10.1186/s12879-025-10900-ySevere fever with thrombocytopenia syndromeDisseminated intravascular coagulationPrevalenceClinical characteristicsOutcomes |
| spellingShingle | Zhongwei Zhang Xue Hu Qian Du Pingzheng Mo Xiaoping Chen Mingqi Luo Qunqun Jiang Liping Deng Yong Xiong Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome BMC Infectious Diseases Severe fever with thrombocytopenia syndrome Disseminated intravascular coagulation Prevalence Clinical characteristics Outcomes |
| title | Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome |
| title_full | Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome |
| title_fullStr | Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome |
| title_full_unstemmed | Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome |
| title_short | Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome |
| title_sort | clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome |
| topic | Severe fever with thrombocytopenia syndrome Disseminated intravascular coagulation Prevalence Clinical characteristics Outcomes |
| url | https://doi.org/10.1186/s12879-025-10900-y |
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