Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis
Bacterial endophthalmitis (BE) is a severe eye infection that often leads to vision loss or blindness. The conventional therapeutic approach entails the administration of intravitreal antibiotic injections, a procedure that is associated with significant discomfort for the patient. Here, we present...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425005010 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850225956468293632 |
|---|---|
| author | Ting Hua Tianzi Zhang Yi Tang Shuo Wang Guowenlie Gao Chunsheng Xiao Pengqi Wan Hong Wu |
| author_facet | Ting Hua Tianzi Zhang Yi Tang Shuo Wang Guowenlie Gao Chunsheng Xiao Pengqi Wan Hong Wu |
| author_sort | Ting Hua |
| collection | DOAJ |
| description | Bacterial endophthalmitis (BE) is a severe eye infection that often leads to vision loss or blindness. The conventional therapeutic approach entails the administration of intravitreal antibiotic injections, a procedure that is associated with significant discomfort for the patient. Here, we present a kind of poly-(L-homoarginine) (C6PLL10-Gua) as a non-invasive alternative for effectively eliminating bacteria in endophthalmitis. The synthesized C6PLL10-Gua effectively kills various bacteria by disrupting cell membranes, without causing bacteria resistance over 14 generations. More importantly, C6PLL10-Gua demonstrated significant tissue permeability both in vivo and in vitro. This kind of C6PLL10-Gua eye drops were capable of effectively traversing the ocular barrier to access the posterior segment of the eye. After being instilled into the conjunctival sac, C6PLL10-Gua enabled rapid (<30 min) and prolonged (>24 h) distribution in the retina via a noncorneal pathway. Furthermore, in a MRSA induced endophthalmitis rat model, topical instillation of C6PLL10-Gua showed significant therapeutic effect, which presenting a promising non-invasive therapeutic approach for managing endophthalmitis. |
| format | Article |
| id | doaj-art-b5f5cb4f265041c4be5b744cbae7923c |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-b5f5cb4f265041c4be5b744cbae7923c2025-08-20T02:05:12ZengElsevierMaterials Today Bio2590-00642025-08-013310193110.1016/j.mtbio.2025.101931Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitisTing Hua0Tianzi Zhang1Yi Tang2Shuo Wang3Guowenlie Gao4Chunsheng Xiao5Pengqi Wan6Hong Wu7Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, China; Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia, 028000, ChinaAffiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia, 028000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Corresponding author.Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, China; Corresponding author.Bacterial endophthalmitis (BE) is a severe eye infection that often leads to vision loss or blindness. The conventional therapeutic approach entails the administration of intravitreal antibiotic injections, a procedure that is associated with significant discomfort for the patient. Here, we present a kind of poly-(L-homoarginine) (C6PLL10-Gua) as a non-invasive alternative for effectively eliminating bacteria in endophthalmitis. The synthesized C6PLL10-Gua effectively kills various bacteria by disrupting cell membranes, without causing bacteria resistance over 14 generations. More importantly, C6PLL10-Gua demonstrated significant tissue permeability both in vivo and in vitro. This kind of C6PLL10-Gua eye drops were capable of effectively traversing the ocular barrier to access the posterior segment of the eye. After being instilled into the conjunctival sac, C6PLL10-Gua enabled rapid (<30 min) and prolonged (>24 h) distribution in the retina via a noncorneal pathway. Furthermore, in a MRSA induced endophthalmitis rat model, topical instillation of C6PLL10-Gua showed significant therapeutic effect, which presenting a promising non-invasive therapeutic approach for managing endophthalmitis.http://www.sciencedirect.com/science/article/pii/S2590006425005010Antibacterial polymersBacterial infectionEndophthalmitisPolypeptidesTopical instillation |
| spellingShingle | Ting Hua Tianzi Zhang Yi Tang Shuo Wang Guowenlie Gao Chunsheng Xiao Pengqi Wan Hong Wu Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis Materials Today Bio Antibacterial polymers Bacterial infection Endophthalmitis Polypeptides Topical instillation |
| title | Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis |
| title_full | Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis |
| title_fullStr | Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis |
| title_full_unstemmed | Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis |
| title_short | Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis |
| title_sort | poly l homoarginine for the non invasive treatment of endophthalmitis |
| topic | Antibacterial polymers Bacterial infection Endophthalmitis Polypeptides Topical instillation |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425005010 |
| work_keys_str_mv | AT tinghua polylhomoarginineforthenoninvasivetreatmentofendophthalmitis AT tianzizhang polylhomoarginineforthenoninvasivetreatmentofendophthalmitis AT yitang polylhomoarginineforthenoninvasivetreatmentofendophthalmitis AT shuowang polylhomoarginineforthenoninvasivetreatmentofendophthalmitis AT guowenliegao polylhomoarginineforthenoninvasivetreatmentofendophthalmitis AT chunshengxiao polylhomoarginineforthenoninvasivetreatmentofendophthalmitis AT pengqiwan polylhomoarginineforthenoninvasivetreatmentofendophthalmitis AT hongwu polylhomoarginineforthenoninvasivetreatmentofendophthalmitis |