Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy
Abstract Background Self‐expandable metallic stent (SEMS) placement is useful for patients with poor oral intake caused by esophageal stricture attributable to malignancy. In this study, we examined the usefulness of esophageal SEMS placement as a palliative treatment and evaluated the prognostic fa...
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| Format: | Article |
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Wiley
2025-04-01
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| Online Access: | https://doi.org/10.1002/deo2.70120 |
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| author | Yasuki Hatayama Hideaki Ishigami Hidehiro Kamezaki Daisuke Murakami Yukiko Shima Kentaro Ishikawa Harutoshi Sugiyama Takayoshi Nishino Makoto Arai |
| author_facet | Yasuki Hatayama Hideaki Ishigami Hidehiro Kamezaki Daisuke Murakami Yukiko Shima Kentaro Ishikawa Harutoshi Sugiyama Takayoshi Nishino Makoto Arai |
| author_sort | Yasuki Hatayama |
| collection | DOAJ |
| description | Abstract Background Self‐expandable metallic stent (SEMS) placement is useful for patients with poor oral intake caused by esophageal stricture attributable to malignancy. In this study, we examined the usefulness of esophageal SEMS placement as a palliative treatment and evaluated the prognostic factors. Materials and methods Patients who underwent esophageal SEMS placement at three regional base hospitals from December 2007 to June 2023 were included in the study. Results Of 73 patients, 57 patients who underwent palliative SEMS placement were evaluated after excluding 16 patients in whom postoperative treatment was possible after SEMS placement. Median survival after SEMS placement was 67 days (mean, 96 ± 16 days). Univariate analysis identified age (≤78 years vs. >78 years), performance status (3 or 4 vs. 1 or 2), the cancer location (other sites vs. gastrointestinal cancer), the resumption of oral intake (failure vs. success), and clinical stage (IVA/IVB vs. III) as prognostic factors after SEMS placement. On multivariate analysis, performance status 3 or 4 (odds ratio [OR] = 2.87, 95% confidence interval [CI] = 1.28–6.45), cancers other than gastrointestinal cancer (OR = 3.75, 95% CI = 1.14–12.3), and failure to resume oral intake (OR = 21.3, 95% CI = 3.40–133.0) were significantly associated with poor prognosis. Conclusions Palliative treatment with SEMS placement was safe, and a high percentage of patients resumed food intake. An inability to resume food intake, poor performance status, and cancer outside the gastrointestinal tract were poor prognostic factors. |
| format | Article |
| id | doaj-art-b5f4dcbc78274eb39287ec1d5ced0d7b |
| institution | OA Journals |
| issn | 2692-4609 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
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| series | DEN Open |
| spelling | doaj-art-b5f4dcbc78274eb39287ec1d5ced0d7b2025-08-20T02:18:56ZengWileyDEN Open2692-46092025-04-0151n/an/a10.1002/deo2.70120Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancyYasuki Hatayama0Hideaki Ishigami1Hidehiro Kamezaki2Daisuke Murakami3Yukiko Shima4Kentaro Ishikawa5Harutoshi Sugiyama6Takayoshi Nishino7Makoto Arai8Department of Gastroenterology Tokyo Women's Medical University Yachiyo Medical Center Chiba JapanDepartment of Gastroenterology Chiba Rosai Hospital Chiba JapanDepartment of Gastroenterology Eastern Chiba Medical Center Chiba JapanDepartment of Gastroenterology Tokyo Women's Medical University Yachiyo Medical Center Chiba JapanDepartment of Gastroenterology Tokyo Women's Medical University Yachiyo Medical Center Chiba JapanDepartment of Gastroenterology Tokyo Women's Medical University Yachiyo Medical Center Chiba JapanDepartment of Gastroenterology Tokyo Women's Medical University Yachiyo Medical Center Chiba JapanDepartment of Gastroenterology Tokyo Women's Medical University Yachiyo Medical Center Chiba JapanDepartment of Gastroenterology Tokyo Women's Medical University Yachiyo Medical Center Chiba JapanAbstract Background Self‐expandable metallic stent (SEMS) placement is useful for patients with poor oral intake caused by esophageal stricture attributable to malignancy. In this study, we examined the usefulness of esophageal SEMS placement as a palliative treatment and evaluated the prognostic factors. Materials and methods Patients who underwent esophageal SEMS placement at three regional base hospitals from December 2007 to June 2023 were included in the study. Results Of 73 patients, 57 patients who underwent palliative SEMS placement were evaluated after excluding 16 patients in whom postoperative treatment was possible after SEMS placement. Median survival after SEMS placement was 67 days (mean, 96 ± 16 days). Univariate analysis identified age (≤78 years vs. >78 years), performance status (3 or 4 vs. 1 or 2), the cancer location (other sites vs. gastrointestinal cancer), the resumption of oral intake (failure vs. success), and clinical stage (IVA/IVB vs. III) as prognostic factors after SEMS placement. On multivariate analysis, performance status 3 or 4 (odds ratio [OR] = 2.87, 95% confidence interval [CI] = 1.28–6.45), cancers other than gastrointestinal cancer (OR = 3.75, 95% CI = 1.14–12.3), and failure to resume oral intake (OR = 21.3, 95% CI = 3.40–133.0) were significantly associated with poor prognosis. Conclusions Palliative treatment with SEMS placement was safe, and a high percentage of patients resumed food intake. An inability to resume food intake, poor performance status, and cancer outside the gastrointestinal tract were poor prognostic factors.https://doi.org/10.1002/deo2.70120canceresophageal stentpalliative careprognosissurvival |
| spellingShingle | Yasuki Hatayama Hideaki Ishigami Hidehiro Kamezaki Daisuke Murakami Yukiko Shima Kentaro Ishikawa Harutoshi Sugiyama Takayoshi Nishino Makoto Arai Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy DEN Open cancer esophageal stent palliative care prognosis survival |
| title | Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy |
| title_full | Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy |
| title_fullStr | Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy |
| title_full_unstemmed | Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy |
| title_short | Efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy |
| title_sort | efficacy of palliative stenting in patients with esophageal obstruction attributable to malignancy |
| topic | cancer esophageal stent palliative care prognosis survival |
| url | https://doi.org/10.1002/deo2.70120 |
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