Review on alcohol exposure associated embryonic stem cell differentiation mechanisms
Alcohol exposure, as a widespread environmental factor, is highly toxic and teratogenic. Embryonic stem cells (ESCs) are pluripotent and key to development, and their gene expression is tightly regulated, allowing the cells to differentiate without self-renewal. Numerous studies showed that alcohol...
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2025-05-01
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| Series: | 环境与职业医学 |
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| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM24434 |
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| author | Jing GAO Bingchun LIU Hong CHEN Peixin XU Xin GUO Jianlong YUAN Yang LIU |
| author_facet | Jing GAO Bingchun LIU Hong CHEN Peixin XU Xin GUO Jianlong YUAN Yang LIU |
| author_sort | Jing GAO |
| collection | DOAJ |
| description | Alcohol exposure, as a widespread environmental factor, is highly toxic and teratogenic. Embryonic stem cells (ESCs) are pluripotent and key to development, and their gene expression is tightly regulated, allowing the cells to differentiate without self-renewal. Numerous studies showed that alcohol is an important factor affecting the differentiation of ESCs. In this paper, we systematically summarized four major molecular mechanisms underlying alcohol associated differentiation of ESCs: (1) inhibition of the Wnt signaling pathway; (2) restriction of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway; (3) alteration of the expression of pluripotent transcription factors; and (4) activation of the nuclear transcriptional program. Through the above mechanisms, alcohol induces aberrant expression of differentiation-related genes and alters the direction of cellular differentiation towards specific lineages, thereby affecting normal embryonic development. Based on the studies on ESCs modeling and other in vitro and in vivo differentiation experiments, the molecular basis of how alcohol affects differentiation by interfering with signaling networks and transcriptional regulation was elucidated, and the results of current research in this field were also summarized, which is crucial for understanding alcohol-mediated toxic effects. |
| format | Article |
| id | doaj-art-b5f05b52967f4214be7a02edd08e1af3 |
| institution | DOAJ |
| issn | 2095-9982 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj-art-b5f05b52967f4214be7a02edd08e1af32025-08-20T03:22:01ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822025-05-0142563764310.11836/JEOM2443424434Review on alcohol exposure associated embryonic stem cell differentiation mechanismsJing GAO0Bingchun LIU1Hong CHEN2Peixin XU3Xin GUO4Jianlong YUAN5Yang LIU6The Affiliated Hospital of Inner Mongolia Medical University Department of Laboratory MedicineThe Affiliated Hospital of Inner Mongolia Medical University Organ Transplantation Center Laboratory/Stem Cell Laboratory/Tumor Cell Gene Detection Application and Research Engineering Laboratory, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, ChinaThe Affiliated Hospital of Inner Mongolia Medical University Department of Laboratory MedicineThe Affiliated Hospital of Inner Mongolia Medical University Department of Laboratory MedicineThe Affiliated Hospital of Inner Mongolia Medical University Department of Laboratory MedicineThe Affiliated Hospital of Inner Mongolia Medical University Department of Laboratory MedicineThe Affiliated Hospital of Inner Mongolia Medical University Department of Laboratory MedicineAlcohol exposure, as a widespread environmental factor, is highly toxic and teratogenic. Embryonic stem cells (ESCs) are pluripotent and key to development, and their gene expression is tightly regulated, allowing the cells to differentiate without self-renewal. Numerous studies showed that alcohol is an important factor affecting the differentiation of ESCs. In this paper, we systematically summarized four major molecular mechanisms underlying alcohol associated differentiation of ESCs: (1) inhibition of the Wnt signaling pathway; (2) restriction of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway; (3) alteration of the expression of pluripotent transcription factors; and (4) activation of the nuclear transcriptional program. Through the above mechanisms, alcohol induces aberrant expression of differentiation-related genes and alters the direction of cellular differentiation towards specific lineages, thereby affecting normal embryonic development. Based on the studies on ESCs modeling and other in vitro and in vivo differentiation experiments, the molecular basis of how alcohol affects differentiation by interfering with signaling networks and transcriptional regulation was elucidated, and the results of current research in this field were also summarized, which is crucial for understanding alcohol-mediated toxic effects.http://www.jeom.org/article/cn/10.11836/JEOM24434alcohol exposureembryonic stem celldifferentiationtoxic effect |
| spellingShingle | Jing GAO Bingchun LIU Hong CHEN Peixin XU Xin GUO Jianlong YUAN Yang LIU Review on alcohol exposure associated embryonic stem cell differentiation mechanisms 环境与职业医学 alcohol exposure embryonic stem cell differentiation toxic effect |
| title | Review on alcohol exposure associated embryonic stem cell differentiation mechanisms |
| title_full | Review on alcohol exposure associated embryonic stem cell differentiation mechanisms |
| title_fullStr | Review on alcohol exposure associated embryonic stem cell differentiation mechanisms |
| title_full_unstemmed | Review on alcohol exposure associated embryonic stem cell differentiation mechanisms |
| title_short | Review on alcohol exposure associated embryonic stem cell differentiation mechanisms |
| title_sort | review on alcohol exposure associated embryonic stem cell differentiation mechanisms |
| topic | alcohol exposure embryonic stem cell differentiation toxic effect |
| url | http://www.jeom.org/article/cn/10.11836/JEOM24434 |
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