Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors
Mucinous ovarian carcinoma is a rare histological form of epithelial ovarian cancer. These tumors demonstrate poor objective response to standard chemotherapy regimens for epithelial ovarian cancer and PARP inhibitors maintenance therapy, resulting in short overall and disease-free survival, as well...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2025-03-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/1326 |
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| _version_ | 1849400974424145920 |
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| author | A. G. Kedrova T. A. Greyan |
| author_facet | A. G. Kedrova T. A. Greyan |
| author_sort | A. G. Kedrova |
| collection | DOAJ |
| description | Mucinous ovarian carcinoma is a rare histological form of epithelial ovarian cancer. These tumors demonstrate poor objective response to standard chemotherapy regimens for epithelial ovarian cancer and PARP inhibitors maintenance therapy, resulting in short overall and disease-free survival, as well as a poor prognosis in patients with advanced disease. Macroscopically, mucinous ovarian carcinoma is characterized by the presence of mucus in the cystic cavity, consisting mainly of mucin. This review examines in detail the role of mucins in the pathogenesis and therapy of mucinous ovarian carcinoma in the context of the formation of chemoresistance and a possible point for targeted therapy. |
| format | Article |
| id | doaj-art-b5f010ae2a5246e7bc79281063c0c747 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2025-03-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-b5f010ae2a5246e7bc79281063c0c7472025-08-20T03:37:52ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272025-03-0120412713210.17650/1994-4098-2024-20-4-127-132886Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumorsA. G. Kedrova0T. A. Greyan1Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian FederationFederal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian FederationMucinous ovarian carcinoma is a rare histological form of epithelial ovarian cancer. These tumors demonstrate poor objective response to standard chemotherapy regimens for epithelial ovarian cancer and PARP inhibitors maintenance therapy, resulting in short overall and disease-free survival, as well as a poor prognosis in patients with advanced disease. Macroscopically, mucinous ovarian carcinoma is characterized by the presence of mucus in the cystic cavity, consisting mainly of mucin. This review examines in detail the role of mucins in the pathogenesis and therapy of mucinous ovarian carcinoma in the context of the formation of chemoresistance and a possible point for targeted therapy.https://ojrs.abvpress.ru/ojrs/article/view/1326mucincarcinogenesismucinous ovarian carcinomaovarian cancer |
| spellingShingle | A. G. Kedrova T. A. Greyan Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors Опухоли женской репродуктивной системы mucin carcinogenesis mucinous ovarian carcinoma ovarian cancer |
| title | Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors |
| title_full | Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors |
| title_fullStr | Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors |
| title_full_unstemmed | Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors |
| title_short | Mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors |
| title_sort | mucins as a factor of carcinogenesis and a potential target for therapy of mucinous ovarian tumors |
| topic | mucin carcinogenesis mucinous ovarian carcinoma ovarian cancer |
| url | https://ojrs.abvpress.ru/ojrs/article/view/1326 |
| work_keys_str_mv | AT agkedrova mucinsasafactorofcarcinogenesisandapotentialtargetfortherapyofmucinousovariantumors AT tagreyan mucinsasafactorofcarcinogenesisandapotentialtargetfortherapyofmucinousovariantumors |