Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas
Matrix metalloproteinases (MMPs) are involved in remodeling the extracellular matrix, but also participate in the development of physiopathologic processes. As they are overexpressed in different types of epithelial cancers, it has been suggested that their level expression could explain the differe...
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| Format: | Article |
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Elsevier
2022-05-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426822000306 |
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| author | Josué Zuriel Ortiz-García Susana Munguía-Robledo Juan José Estrada-Orozco Carlos Licéaga-Escalera Mario A. Rodríguez |
| author_facet | Josué Zuriel Ortiz-García Susana Munguía-Robledo Juan José Estrada-Orozco Carlos Licéaga-Escalera Mario A. Rodríguez |
| author_sort | Josué Zuriel Ortiz-García |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs) are involved in remodeling the extracellular matrix, but also participate in the development of physiopathologic processes. As they are overexpressed in different types of epithelial cancers, it has been suggested that their level expression could explain the different biological behavior between odontogenic cysts and tumors. Here, we compared the expression level and proteolytic activities of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas. We found similar expression of MMP-2 in all tissues, but a higher activity in cystic and tumor lesions than follicles. On the other hand, MMP-9 expression and activity was greater in cysts and ameloblastoma than in follicles. However, no differences were found in expression or activity of both MMPs between cystic and tumor injuries, suggesting that they could participate in the growth of these lesions, but they cannot define their different biological behavior. |
| format | Article |
| id | doaj-art-b5efd9dc5e094536ab8167d2bdd853ff |
| institution | OA Journals |
| issn | 2212-4268 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-b5efd9dc5e094536ab8167d2bdd853ff2025-08-20T02:01:58ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682022-05-0112333934210.1016/j.jobcr.2022.03.014Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomasJosué Zuriel Ortiz-García0Susana Munguía-Robledo1Juan José Estrada-Orozco2Carlos Licéaga-Escalera3Mario A. Rodríguez4Departmento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, MexicoDepartmento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, MexicoHospital General de Zona 2-A. Instituto Mexicano del Seguro Social, Mexico City, MexicoDepartamento de Cirugía Maxilofacial, Hospital Juárez de México, Mexico City, MexicoDepartmento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico; Corresponding author. Departmento de Infectómica y Patogénesis Molecular. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City, 07360, MexicoMatrix metalloproteinases (MMPs) are involved in remodeling the extracellular matrix, but also participate in the development of physiopathologic processes. As they are overexpressed in different types of epithelial cancers, it has been suggested that their level expression could explain the different biological behavior between odontogenic cysts and tumors. Here, we compared the expression level and proteolytic activities of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas. We found similar expression of MMP-2 in all tissues, but a higher activity in cystic and tumor lesions than follicles. On the other hand, MMP-9 expression and activity was greater in cysts and ameloblastoma than in follicles. However, no differences were found in expression or activity of both MMPs between cystic and tumor injuries, suggesting that they could participate in the growth of these lesions, but they cannot define their different biological behavior.http://www.sciencedirect.com/science/article/pii/S2212426822000306Dentigerous cystOdontogenic keratocystUnicystic ameloblastomaMetalloproteinases |
| spellingShingle | Josué Zuriel Ortiz-García Susana Munguía-Robledo Juan José Estrada-Orozco Carlos Licéaga-Escalera Mario A. Rodríguez Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas Journal of Oral Biology and Craniofacial Research Dentigerous cyst Odontogenic keratocyst Unicystic ameloblastoma Metalloproteinases |
| title | Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas |
| title_full | Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas |
| title_fullStr | Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas |
| title_full_unstemmed | Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas |
| title_short | Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas |
| title_sort | expression level and proteolytic activity of mmp 2 and mmp 9 in dental follicles dentigerous cysts odontogenic keratocysts and unicystic ameloblastomas |
| topic | Dentigerous cyst Odontogenic keratocyst Unicystic ameloblastoma Metalloproteinases |
| url | http://www.sciencedirect.com/science/article/pii/S2212426822000306 |
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