The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol
ABSTRACT Background Post‐stroke cognitive impairment (PSCI) is a common complication following stroke, with limited effective treatments. This randomized controlled trial aims to evaluate the efficacy of two non‐pharmacological interventions—electroacupuncture therapy (EA) and herbal olfactory thera...
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Wiley
2025-07-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70631 |
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| author | Ying Dandan Zhao Jingting Wang Minzhe Cai Zhuoyue Li Xinyun |
| author_facet | Ying Dandan Zhao Jingting Wang Minzhe Cai Zhuoyue Li Xinyun |
| author_sort | Ying Dandan |
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| description | ABSTRACT Background Post‐stroke cognitive impairment (PSCI) is a common complication following stroke, with limited effective treatments. This randomized controlled trial aims to evaluate the efficacy of two non‐pharmacological interventions—electroacupuncture therapy (EA) and herbal olfactory therapy (HOT)—in improving cognitive function in PSCI patients, both as standalone treatments and in combination. Methods This parallel‐group, assessor‐blinded, randomized controlled trial will recruit 210 PSCI patients, randomly assigned to one of six groups: control, EA, HOT, combination therapy, sham therapy, or the healthy (ratio 1:1:1:1:1:1). All participants will receive standard cognitive training and basic medical care. The EA group will receive 4 weeks of electro‐acupuncture at specific acupoints. The HOT group will receive 4 weeks of aromatic inhalation therapy using Acorus tatarinowii volatile oil. The combination group will receive both interventions. The primary outcome measure is cognitive function, assessed using the Montreal cognitive assessment (MoCA) at baseline, week 4, and week 8. Secondary outcomes include the mini‐mental state examination (MMSE), functional magnetic resonance imaging (fMRI), near‐infrared spectroscopy (fNIRS), and anxiety assessment using the state‐trait anxiety inventory (STAI) at baseline and week 4. Data analysis will be conducted using a modified intention‐to‐treat approach. Aims This study aims to evaluate the clinical efficacy of EA at cervical acupoints combined with HOT for PSCI, with a specific focus on determining the therapeutic superiority of this combined approach over monotherapy interventions. |
| format | Article |
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| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj-art-b5e8d1382e604ee09c1bdd500d2349212025-08-20T03:58:48ZengWileyBrain and Behavior2162-32792025-07-01157n/an/a10.1002/brb3.70631The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial ProtocolYing Dandan0Zhao Jingting1Wang Minzhe2Cai Zhuoyue3Li Xinyun4Shaoxing Second Hospital Medical Community General Hospital Shaoxing Zhejiang ChinaCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital Hangzhou Medical College Hangzhou Zhejiang ChinaCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital Hangzhou Medical College Hangzhou Zhejiang ChinaSchool of Rehabilitation Hangzhou Medical College Hangzhou Zhejiang ChinaSchool of Rehabilitation Hangzhou Medical College Hangzhou Zhejiang ChinaABSTRACT Background Post‐stroke cognitive impairment (PSCI) is a common complication following stroke, with limited effective treatments. This randomized controlled trial aims to evaluate the efficacy of two non‐pharmacological interventions—electroacupuncture therapy (EA) and herbal olfactory therapy (HOT)—in improving cognitive function in PSCI patients, both as standalone treatments and in combination. Methods This parallel‐group, assessor‐blinded, randomized controlled trial will recruit 210 PSCI patients, randomly assigned to one of six groups: control, EA, HOT, combination therapy, sham therapy, or the healthy (ratio 1:1:1:1:1:1). All participants will receive standard cognitive training and basic medical care. The EA group will receive 4 weeks of electro‐acupuncture at specific acupoints. The HOT group will receive 4 weeks of aromatic inhalation therapy using Acorus tatarinowii volatile oil. The combination group will receive both interventions. The primary outcome measure is cognitive function, assessed using the Montreal cognitive assessment (MoCA) at baseline, week 4, and week 8. Secondary outcomes include the mini‐mental state examination (MMSE), functional magnetic resonance imaging (fMRI), near‐infrared spectroscopy (fNIRS), and anxiety assessment using the state‐trait anxiety inventory (STAI) at baseline and week 4. Data analysis will be conducted using a modified intention‐to‐treat approach. Aims This study aims to evaluate the clinical efficacy of EA at cervical acupoints combined with HOT for PSCI, with a specific focus on determining the therapeutic superiority of this combined approach over monotherapy interventions.https://doi.org/10.1002/brb3.70631cognitiveelectric neck acupunctureherbal olfactory therapyRCTstroke |
| spellingShingle | Ying Dandan Zhao Jingting Wang Minzhe Cai Zhuoyue Li Xinyun The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol Brain and Behavior cognitive electric neck acupuncture herbal olfactory therapy RCT stroke |
| title | The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol |
| title_full | The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol |
| title_fullStr | The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol |
| title_full_unstemmed | The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol |
| title_short | The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol |
| title_sort | therapeutic effects of acorus tatarinowii volatile oil and electroacupuncture in post stroke cognitive impairment patients a clinical trial protocol |
| topic | cognitive electric neck acupuncture herbal olfactory therapy RCT stroke |
| url | https://doi.org/10.1002/brb3.70631 |
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