Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD

Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD

Abstract Recent research has highlighted widespread dysregulation of alternative polyadenylation in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Here, we identify significant disruptions to 3` UTR polyadenylation in the ALS/FTLD-TDP mous...

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Bibliographic Details
Main Authors: Randall J. Eck, Paul N. Valdmanis, Nicole F. Liachko, Brian C. Kraemer
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Brain
Subjects:
ALS
FTLD
TDP-43
Alternative polyadenylation
Online Access:https://doi.org/10.1186/s13041-025-01174-1
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