Colitis as the Initial Presentation of Eosinophilic Granulomatosis with Polyangiitis
A male patient in his early sixties with recurrent diarrhea was transferred to our hospital. The patient did not have any pulmonary or upper respiratory symptoms. He was noted to have peripheral eosinophilia. Further workup revealed a negative antineutrophilic cytoplasmic antibody titer but a positi...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2023/6620826 |
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| author | Sharika Gopakumar Menon Steven Hugenberg Ahmad M. Alkashash Jingmei Lin Arya M. Iranmanesh |
| author_facet | Sharika Gopakumar Menon Steven Hugenberg Ahmad M. Alkashash Jingmei Lin Arya M. Iranmanesh |
| author_sort | Sharika Gopakumar Menon |
| collection | DOAJ |
| description | A male patient in his early sixties with recurrent diarrhea was transferred to our hospital. The patient did not have any pulmonary or upper respiratory symptoms. He was noted to have peripheral eosinophilia. Further workup revealed a negative antineutrophilic cytoplasmic antibody titer but a positive myeloperoxidase antibody and positive proteinase 3 antibodies. A colon biopsy also revealed eosinophilic-rich granulomas in the mucosa, confirming a diagnosis of eosinophilic granulomatosis with polyangiitis. On cardiac imaging, eosinophilic myocarditis was also discovered. To treat active severe EGPA, the patient received high-dose corticosteroids and intravenous cyclophosphamide. The occurrence of gastrointestinal involvement as an initial manifestation of eosinophilic granulomatosis with polyangiitis is infrequent, emphasizing the significance of its recognition. This case underscores the importance of identifying and diagnosing such atypical presentations to facilitate timely and appropriate management. |
| format | Article |
| id | doaj-art-b5e7afa81f8541cd8e33806aa45cbcc1 |
| institution | OA Journals |
| issn | 2090-6897 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-b5e7afa81f8541cd8e33806aa45cbcc12025-08-20T02:23:20ZengWileyCase Reports in Rheumatology2090-68972023-01-01202310.1155/2023/6620826Colitis as the Initial Presentation of Eosinophilic Granulomatosis with PolyangiitisSharika Gopakumar Menon0Steven Hugenberg1Ahmad M. Alkashash2Jingmei Lin3Arya M. Iranmanesh4Department of MedicineDepartment of MedicineDepartment of PathologyDepartment of PathologyDepartment of RadiologyA male patient in his early sixties with recurrent diarrhea was transferred to our hospital. The patient did not have any pulmonary or upper respiratory symptoms. He was noted to have peripheral eosinophilia. Further workup revealed a negative antineutrophilic cytoplasmic antibody titer but a positive myeloperoxidase antibody and positive proteinase 3 antibodies. A colon biopsy also revealed eosinophilic-rich granulomas in the mucosa, confirming a diagnosis of eosinophilic granulomatosis with polyangiitis. On cardiac imaging, eosinophilic myocarditis was also discovered. To treat active severe EGPA, the patient received high-dose corticosteroids and intravenous cyclophosphamide. The occurrence of gastrointestinal involvement as an initial manifestation of eosinophilic granulomatosis with polyangiitis is infrequent, emphasizing the significance of its recognition. This case underscores the importance of identifying and diagnosing such atypical presentations to facilitate timely and appropriate management.http://dx.doi.org/10.1155/2023/6620826 |
| spellingShingle | Sharika Gopakumar Menon Steven Hugenberg Ahmad M. Alkashash Jingmei Lin Arya M. Iranmanesh Colitis as the Initial Presentation of Eosinophilic Granulomatosis with Polyangiitis Case Reports in Rheumatology |
| title | Colitis as the Initial Presentation of Eosinophilic Granulomatosis with Polyangiitis |
| title_full | Colitis as the Initial Presentation of Eosinophilic Granulomatosis with Polyangiitis |
| title_fullStr | Colitis as the Initial Presentation of Eosinophilic Granulomatosis with Polyangiitis |
| title_full_unstemmed | Colitis as the Initial Presentation of Eosinophilic Granulomatosis with Polyangiitis |
| title_short | Colitis as the Initial Presentation of Eosinophilic Granulomatosis with Polyangiitis |
| title_sort | colitis as the initial presentation of eosinophilic granulomatosis with polyangiitis |
| url | http://dx.doi.org/10.1155/2023/6620826 |
| work_keys_str_mv | AT sharikagopakumarmenon colitisastheinitialpresentationofeosinophilicgranulomatosiswithpolyangiitis AT stevenhugenberg colitisastheinitialpresentationofeosinophilicgranulomatosiswithpolyangiitis AT ahmadmalkashash colitisastheinitialpresentationofeosinophilicgranulomatosiswithpolyangiitis AT jingmeilin colitisastheinitialpresentationofeosinophilicgranulomatosiswithpolyangiitis AT aryamiranmanesh colitisastheinitialpresentationofeosinophilicgranulomatosiswithpolyangiitis |