Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression
Abstract The research of morphogenesis of liver fibrosis in 589 patients with chronic viral hepatitis, alcoholic and non-alcoholic steatohepatitis has shown that perisinusoidal-centrоlobular liver fibrosis can develop at chronic liver diseases. This type of liver fibrosis is characterized by coll...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2012-12-01
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| Series: | Patologìâ |
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| Online Access: | http://pat.zsmu.edu.ua/article/view/17012/14702 |
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| author | V.A. Tumanskiy Yu.A. Shebeko |
| author_facet | V.A. Tumanskiy Yu.A. Shebeko |
| author_sort | V.A. Tumanskiy |
| collection | DOAJ |
| description | Abstract
The research of morphogenesis of liver fibrosis in 589 patients with chronic viral hepatitis, alcoholic and non-alcoholic steatohepatitis has shown that perisinusoidal-centrоlobular liver fibrosis can develop at chronic liver diseases. This type of liver fibrosis is characterized by collagen deposition and fibrosis in perisinusoidal space of Disse in 3rd-2nd zones of liver acinus and around centrolobular veins at minimal or absent portal fibrosis. Severe perisinusoidal-central-lobular liver fibrosis is manifested by symptoms of portal hypertention before cirrhosis development. |
| format | Article |
| id | doaj-art-b5e6b33dbebd40aabe3b13e3aceaee76 |
| institution | DOAJ |
| issn | 2306-8027 2310-1237 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Patologìâ |
| spelling | doaj-art-b5e6b33dbebd40aabe3b13e3aceaee762025-08-20T03:04:43ZengZaporizhzhia State Medical and Pharmaceutical UniversityPatologìâ2306-80272310-12372012-12-013596410.14739/2310-1237.2012.3.17012Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progressionV.A. TumanskiyYu.A. ShebekoAbstract The research of morphogenesis of liver fibrosis in 589 patients with chronic viral hepatitis, alcoholic and non-alcoholic steatohepatitis has shown that perisinusoidal-centrоlobular liver fibrosis can develop at chronic liver diseases. This type of liver fibrosis is characterized by collagen deposition and fibrosis in perisinusoidal space of Disse in 3rd-2nd zones of liver acinus and around centrolobular veins at minimal or absent portal fibrosis. Severe perisinusoidal-central-lobular liver fibrosis is manifested by symptoms of portal hypertention before cirrhosis development.http://pat.zsmu.edu.ua/article/view/17012/14702perisinusoidal-centrolobular liver fibrosisportal hypertension |
| spellingShingle | V.A. Tumanskiy Yu.A. Shebeko Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression Patologìâ perisinusoidal-centrolobular liver fibrosis portal hypertension |
| title | Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression |
| title_full | Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression |
| title_fullStr | Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression |
| title_full_unstemmed | Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression |
| title_short | Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression |
| title_sort | рerisinusoidal centrolobular liver fibrosis features of morphogenegis and parameters of progression |
| topic | perisinusoidal-centrolobular liver fibrosis portal hypertension |
| url | http://pat.zsmu.edu.ua/article/view/17012/14702 |
| work_keys_str_mv | AT vatumanskiy rerisinusoidalcentrolobularliverfibrosisfeaturesofmorphogenegisandparametersofprogression AT yuashebeko rerisinusoidalcentrolobularliverfibrosisfeaturesofmorphogenegisandparametersofprogression |