Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy
Abstract Most acute ischemic stroke patients with large vessel occlusion require stent implantation post-thrombectomy for complete recanalization, yet they exhibit a high rate of poor prognosis due to ischemia-reperfusion injury. Thus, combining reperfusion therapy with neuroprotective treatment off...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61199-x |
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| author | Hongkang Zhang Yang Zhang Lili Sheng Xiaofeng Cao Chuanjie Wu Baoying Song Yunong Shen Zikai Xu Ge Song Hao Sun Qing Liu Xunming Ji Miaowen Jiang Ming Li Yufeng Zheng |
| author_facet | Hongkang Zhang Yang Zhang Lili Sheng Xiaofeng Cao Chuanjie Wu Baoying Song Yunong Shen Zikai Xu Ge Song Hao Sun Qing Liu Xunming Ji Miaowen Jiang Ming Li Yufeng Zheng |
| author_sort | Hongkang Zhang |
| collection | DOAJ |
| description | Abstract Most acute ischemic stroke patients with large vessel occlusion require stent implantation post-thrombectomy for complete recanalization, yet they exhibit a high rate of poor prognosis due to ischemia-reperfusion injury. Thus, combining reperfusion therapy with neuroprotective treatment offers significant advantages. This study introduces a novel Mg2+ eluting stent by incorporating neuroprotective MgSO4 particles into a PLCL (poly (l-lactide-co-ε-caprolactone)) substrate using 3D printing technology. A novel MgSO4-particle/Mg2+-ions combined-mechanical reinforcement mechanism was introduced. Subsequently, the neuroprotective efficacy of the stents was validated through oxygen-glucose deprivation/reoxygenation-injured neuron cells in vitro and via the transient middle cerebral artery occlusion rat model to emulate human brain ischemia/reperfusion injury in vivo. The staged-release of Mg2+ is supposed to provide sequential neuroprotection that aligns with the treatment window for acute ischemic stroke. This study marks the first development of biodegradable neuroprotective brain stents and presents an effective strategy to alleviate cerebral ischemia-reperfusion injury. |
| format | Article |
| id | doaj-art-b5e655b857b9401b9bfb7a9574f8b0cb |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-b5e655b857b9401b9bfb7a9574f8b0cb2025-08-20T03:46:23ZengNature PortfolioNature Communications2041-17232025-07-0116112210.1038/s41467-025-61199-xMechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapyHongkang Zhang0Yang Zhang1Lili Sheng2Xiaofeng Cao3Chuanjie Wu4Baoying Song5Yunong Shen6Zikai Xu7Ge Song8Hao Sun9Qing Liu10Xunming Ji11Miaowen Jiang12Ming Li13Yufeng Zheng14School of Materials Science and Engineering, Peking UniversityChina-America Institute of Neuroscience and and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical UniversityBeijing Advanced Medical Technologies, Ltd. IncSchool of Materials Science and Engineering, Peking UniversityChina-America Institute of Neuroscience and and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical UniversitySchool of Materials Science and Engineering, Peking UniversitySchool of Life science University of GlasgowBeijing Advanced Medical Technologies, Ltd. IncBeijing Advanced Medical Technologies, Ltd. IncBeijing Advanced Medical Technologies, Ltd. IncChina-America Institute of Neuroscience and and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical UniversityBeijing Institute of Brain Disorders, Capital Medical UniversityChina-America Institute of Neuroscience and and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical UniversitySchool of Materials Science and Engineering, Peking UniversityAbstract Most acute ischemic stroke patients with large vessel occlusion require stent implantation post-thrombectomy for complete recanalization, yet they exhibit a high rate of poor prognosis due to ischemia-reperfusion injury. Thus, combining reperfusion therapy with neuroprotective treatment offers significant advantages. This study introduces a novel Mg2+ eluting stent by incorporating neuroprotective MgSO4 particles into a PLCL (poly (l-lactide-co-ε-caprolactone)) substrate using 3D printing technology. A novel MgSO4-particle/Mg2+-ions combined-mechanical reinforcement mechanism was introduced. Subsequently, the neuroprotective efficacy of the stents was validated through oxygen-glucose deprivation/reoxygenation-injured neuron cells in vitro and via the transient middle cerebral artery occlusion rat model to emulate human brain ischemia/reperfusion injury in vivo. The staged-release of Mg2+ is supposed to provide sequential neuroprotection that aligns with the treatment window for acute ischemic stroke. This study marks the first development of biodegradable neuroprotective brain stents and presents an effective strategy to alleviate cerebral ischemia-reperfusion injury.https://doi.org/10.1038/s41467-025-61199-x |
| spellingShingle | Hongkang Zhang Yang Zhang Lili Sheng Xiaofeng Cao Chuanjie Wu Baoying Song Yunong Shen Zikai Xu Ge Song Hao Sun Qing Liu Xunming Ji Miaowen Jiang Ming Li Yufeng Zheng Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy Nature Communications |
| title | Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy |
| title_full | Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy |
| title_fullStr | Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy |
| title_full_unstemmed | Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy |
| title_short | Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy |
| title_sort | mechanically robust neuroprotective stent by sequential mg ions release for ischemic stroke therapy |
| url | https://doi.org/10.1038/s41467-025-61199-x |
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