Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs
Abstract This study examined the different effects of high-fat and capsicum diets on the digestive organs of guinea pigs. Hartley guinea pigs (n = 24) were divided into the high-fat diet (HFD), capsicum diet (CD), and control (C) groups. Guinea pigs in the C, HFD, and CD groups received maintenance...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-93583-4 |
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| author | Wen-Xiang Guan Zhuo-Lan Xiao-Jun Luo Jing-Xian Gao Chang-Xi Bai |
| author_facet | Wen-Xiang Guan Zhuo-Lan Xiao-Jun Luo Jing-Xian Gao Chang-Xi Bai |
| author_sort | Wen-Xiang Guan |
| collection | DOAJ |
| description | Abstract This study examined the different effects of high-fat and capsicum diets on the digestive organs of guinea pigs. Hartley guinea pigs (n = 24) were divided into the high-fat diet (HFD), capsicum diet (CD), and control (C) groups. Guinea pigs in the C, HFD, and CD groups received maintenance feed, high-fat, and capsicum diets, respectively. After 12 weeks of modelling, serum samples were collected for biochemical analysis. Enzyme-linked immunosorbent assay was used to quantify interleukin-1β, interleukin-6, and tumour necrosis factor-α, while haematoxylin-eosin staining was used to observe morphological changes. Blood lipid levels and inflammatory markers in the serum of guinea pigs in HFD and CD groups were significantly elevated than those in the serum of guinea pigs in the C group (P < 0.01). Inflammation and blood lipid disorders were more severe among guinea pigs in the HFD group than among those in the CD and C groups (P < 0.001). Pathological examinations revealed that high-fat and capsicum diets induce damage to the liver, stomach, gallbladder, and colon. Specifically, high-fat diets exhibited more significant effects. High-fat or capsicum diet consumption can damage the digestive organs, causing abnormal lipid metabolism; however, high-fat diets exhibit more significant effects on the digestive organs. |
| format | Article |
| id | doaj-art-b5e547a8aa044014be9d815f47164573 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-b5e547a8aa044014be9d815f471645732025-08-20T03:48:18ZengNature PortfolioScientific Reports2045-23222025-05-0115111010.1038/s41598-025-93583-4Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigsWen-Xiang Guan0Zhuo-Lan1Xiao-Jun Luo2Jing-Xian Gao3Chang-Xi Bai4Inner Mongolia Medical UniversityInner Mongolia Medical UniversityHulunbuir City Chinese-Mongolian HospitalInner Mongolia Medical UniversityInner Mongolia Medical UniversityAbstract This study examined the different effects of high-fat and capsicum diets on the digestive organs of guinea pigs. Hartley guinea pigs (n = 24) were divided into the high-fat diet (HFD), capsicum diet (CD), and control (C) groups. Guinea pigs in the C, HFD, and CD groups received maintenance feed, high-fat, and capsicum diets, respectively. After 12 weeks of modelling, serum samples were collected for biochemical analysis. Enzyme-linked immunosorbent assay was used to quantify interleukin-1β, interleukin-6, and tumour necrosis factor-α, while haematoxylin-eosin staining was used to observe morphological changes. Blood lipid levels and inflammatory markers in the serum of guinea pigs in HFD and CD groups were significantly elevated than those in the serum of guinea pigs in the C group (P < 0.01). Inflammation and blood lipid disorders were more severe among guinea pigs in the HFD group than among those in the CD and C groups (P < 0.001). Pathological examinations revealed that high-fat and capsicum diets induce damage to the liver, stomach, gallbladder, and colon. Specifically, high-fat diets exhibited more significant effects. High-fat or capsicum diet consumption can damage the digestive organs, causing abnormal lipid metabolism; however, high-fat diets exhibit more significant effects on the digestive organs.https://doi.org/10.1038/s41598-025-93583-4High-fat dietCapsicum dietDigestive organsLipid metabolismComparative medicine |
| spellingShingle | Wen-Xiang Guan Zhuo-Lan Xiao-Jun Luo Jing-Xian Gao Chang-Xi Bai Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs Scientific Reports High-fat diet Capsicum diet Digestive organs Lipid metabolism Comparative medicine |
| title | Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs |
| title_full | Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs |
| title_fullStr | Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs |
| title_full_unstemmed | Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs |
| title_short | Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs |
| title_sort | comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs |
| topic | High-fat diet Capsicum diet Digestive organs Lipid metabolism Comparative medicine |
| url | https://doi.org/10.1038/s41598-025-93583-4 |
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