The Kidney in Heart Failure: The Role of Venous Congestion
Heart failure can lead to renal impairment, an interaction now termed “cardiorenal syndrome.” The prevalent physiological explanation for the renal impairment that accompanies heart failure centers around the forward failure hypothesis, which emphasizes the role of left ventricular dysfunction in ca...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2022-09-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1121 |
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| author | Alvaro Tamayo-Gutierrez Hassan N. Ibrahim |
| author_facet | Alvaro Tamayo-Gutierrez Hassan N. Ibrahim |
| author_sort | Alvaro Tamayo-Gutierrez |
| collection | DOAJ |
| description | Heart failure can lead to renal impairment, an interaction now termed “cardiorenal syndrome.” The prevalent physiological explanation for the renal impairment that accompanies heart failure centers around the forward failure hypothesis, which emphasizes the role of left ventricular dysfunction in causing edema, and the backward failure hypothesis, which singles out venous congestion as the dominant mechanism of edema and reduced glomerular filtration rate. In this review, we provide an appraisal on venous congestion, an extremely important contributor that has received little attention. We also summarize the pharmacology of loop diuretics, explain current understanding of diuretic resistance, and address controversies regarding decongestive treatments. |
| format | Article |
| id | doaj-art-b5e317c3b2bd4bb484a587be98eada75 |
| institution | Kabale University |
| issn | 1947-6108 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-b5e317c3b2bd4bb484a587be98eada752025-08-20T03:25:50ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082022-09-0118441010.14797/mdcvj.1121849The Kidney in Heart Failure: The Role of Venous CongestionAlvaro Tamayo-Gutierrez0https://orcid.org/0000-0001-5536-4926Hassan N. Ibrahim1https://orcid.org/0000-0002-1567-9592Division of Renal Diseases and Hypertension, Houston Methodist Hospital, Houston, TexasDivision of Kidney Diseases, Hypertension & Transplantation, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TexasHeart failure can lead to renal impairment, an interaction now termed “cardiorenal syndrome.” The prevalent physiological explanation for the renal impairment that accompanies heart failure centers around the forward failure hypothesis, which emphasizes the role of left ventricular dysfunction in causing edema, and the backward failure hypothesis, which singles out venous congestion as the dominant mechanism of edema and reduced glomerular filtration rate. In this review, we provide an appraisal on venous congestion, an extremely important contributor that has received little attention. We also summarize the pharmacology of loop diuretics, explain current understanding of diuretic resistance, and address controversies regarding decongestive treatments.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1121heart failurecardiorenal syndromevenous congestionglomerular filtration rate |
| spellingShingle | Alvaro Tamayo-Gutierrez Hassan N. Ibrahim The Kidney in Heart Failure: The Role of Venous Congestion Methodist DeBakey Cardiovascular Journal heart failure cardiorenal syndrome venous congestion glomerular filtration rate |
| title | The Kidney in Heart Failure: The Role of Venous Congestion |
| title_full | The Kidney in Heart Failure: The Role of Venous Congestion |
| title_fullStr | The Kidney in Heart Failure: The Role of Venous Congestion |
| title_full_unstemmed | The Kidney in Heart Failure: The Role of Venous Congestion |
| title_short | The Kidney in Heart Failure: The Role of Venous Congestion |
| title_sort | kidney in heart failure the role of venous congestion |
| topic | heart failure cardiorenal syndrome venous congestion glomerular filtration rate |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1121 |
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