URTICARIAL ADVERSE DRUG REACTIONS TO ACE INHIBITORS AND BETA-BLOCKERS
PURPOSE. To evaluate the incidence of urticarial adverse drug reactions (ADRs) to ACE inhibitors and beta-blockers, patient demographics, drug causality, and treatment outcome. METHODS. An epidemiological study including 154 patients with urticarial ADRs, out of a total of 3554 hospitalized patien...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Trakia University
2023-03-01
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| Series: | Trakia Journal of Sciences |
| Subjects: | |
| Online Access: | http://tru.uni-sz.bg/tsj/Volume%2021,%202023,%20Number%201,%20Series%20Biomedical%20Sciences/7_T.Gancheva.pdf |
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| Summary: | PURPOSE. To evaluate the incidence of urticarial adverse drug reactions (ADRs) to ACE inhibitors and
beta-blockers, patient demographics, drug causality, and treatment outcome. METHODS. An
epidemiological study including 154 patients with urticarial ADRs, out of a total of 3554 hospitalized patients
in the Clinic of Dermatology and Venereology, for a 7-year period. ADRs were defined according to the
WHO and the Naranjo algorithm was used for case drug causality assessment.
RESULTS. Urticarial ADRs were found in 4,1% of the study population (≥ 18 years), the average age was
50,2 years, and female prevalence was established. Concomitant cardiovascular diseases were found in 45,2%
of the patients and 30,1% declared using ACE inhibitors and/or beta-blockers. The suspected drug was
withdrawn, and alternative therapy was recommended by a cardiologist. The Naranjo algorithm showed 4.5%
“definitive”, 45,5% “possible”, and 50% “probable” urticarial ADRs. Systemic antihistamines were
administered to all patients and single short corticosteroid courses were added in 81,8%. Clinical recovery
was achieved in 59% of the patients and improvement in 41%. CONCLUSIONS. The need for drug therapy
and hospitalization in severe cases of urticarial ADRs to ACE inhibitors and beta-blockers are factors
contributing to the overall socio-economic burden of ADRs. |
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| ISSN: | 1313-3551 |