The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients
Helicobacter pylori (H. pylori, Hp) colonizes the stomachs of approximately 20%–80% of humans throughout the world. The Word Healthy Organization (WHO) classified H. pylori as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between H. pylori...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/7150959 |
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| author | Wang-Ping Meng Zhong-Qiong Wang Jia-Qi Deng Yi Liu Ming-Ming Deng Mu-Han Lü |
| author_facet | Wang-Ping Meng Zhong-Qiong Wang Jia-Qi Deng Yi Liu Ming-Ming Deng Mu-Han Lü |
| author_sort | Wang-Ping Meng |
| collection | DOAJ |
| description | Helicobacter pylori (H. pylori, Hp) colonizes the stomachs of approximately 20%–80% of humans throughout the world. The Word Healthy Organization (WHO) classified H. pylori as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between H. pylori infection and various extragastric diseases. Functional dyspepsia (FD) is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positive H. pylori strains could explain some of the symptoms of functional dyspepsia. Moreover, CagA-positive H. pylori strains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients. This review describes the mutual effects of H. pylori and hormones in functional dyspepsia and provides new insight into the pathogenesis of functional dyspepsia. |
| format | Article |
| id | doaj-art-b5d67707e490413cb7889c773a8c9c21 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b5d67707e490413cb7889c773a8c9c212025-08-20T03:20:55ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/71509597150959The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia PatientsWang-Ping Meng0Zhong-Qiong Wang1Jia-Qi Deng2Yi Liu3Ming-Ming Deng4Mu-Han Lü5Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, ChinaSchool of Foreign Languages, Southwest Medical University, Luzhou, Sichuan Province 646000, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, ChinaHelicobacter pylori (H. pylori, Hp) colonizes the stomachs of approximately 20%–80% of humans throughout the world. The Word Healthy Organization (WHO) classified H. pylori as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between H. pylori infection and various extragastric diseases. Functional dyspepsia (FD) is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positive H. pylori strains could explain some of the symptoms of functional dyspepsia. Moreover, CagA-positive H. pylori strains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients. This review describes the mutual effects of H. pylori and hormones in functional dyspepsia and provides new insight into the pathogenesis of functional dyspepsia.http://dx.doi.org/10.1155/2016/7150959 |
| spellingShingle | Wang-Ping Meng Zhong-Qiong Wang Jia-Qi Deng Yi Liu Ming-Ming Deng Mu-Han Lü The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients Gastroenterology Research and Practice |
| title | The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients |
| title_full | The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients |
| title_fullStr | The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients |
| title_full_unstemmed | The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients |
| title_short | The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients |
| title_sort | role of h pylori caga in regulating hormones of functional dyspepsia patients |
| url | http://dx.doi.org/10.1155/2016/7150959 |
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