Machine learning identifies PYGM as a macrophage polarization–linked metabolic biomarker in rectal cancer prognosis

Machine learning identifies PYGM as a macrophage polarization–linked metabolic biomarker in rectal cancer prognosis

BackgroundMacrophage polarization plays a pivotal role in shaping the tumor microenvironment and influencing rectal cancer progression. However, the metabolic and prognostic regulators governing this process remain largely undefined.MethodsWe constructed a macrophage polarization gene signature (MPG...

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Bibliographic Details
Main Authors: Chengyuan Xu, Siqi Zhang, Bin Sun, Zicheng Yu, Hailong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
rectal cancer
macrophage polarization
PYGM
metabolism
prognosis
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1639303/full
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