Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy
This review presents the characteristics of the cellular metabolism of methionine, as well as known data on the mechanisms of the development of methionine dependence in malignant cells. The possibilities of using a non-methionine diet for the control of the tumor growth in patients with various for...
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| Format: | Article |
| Language: | Russian |
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Practical Medicine Publishing House
2017-07-01
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| Series: | Клиническая онкогематология |
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| Online Access: | http://bloodjournal.ru/wp-content/uploads/2017/09/4.pdf |
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| _version_ | 1849691742788386816 |
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| author | VS Pokrovskii DZh Davydov NV Anufrieva DD Zhdanov EM Treshchalina TV Demidkina EA Morozova |
| author_facet | VS Pokrovskii DZh Davydov NV Anufrieva DD Zhdanov EM Treshchalina TV Demidkina EA Morozova |
| author_sort | VS Pokrovskii |
| collection | DOAJ |
| description | This review presents the characteristics of the cellular metabolism of methionine, as well as known data on the mechanisms of the development of methionine dependence in malignant cells. The possibilities of using a non-methionine diet for the control of the tumor growth in patients with various forms of cancer are considered. The newest information about methionine-γ-lyase, an enzyme providing elimination of methionine from plasma, is grouped and summarised. Its role as a potential antitumor enzyme is disclosed. Data on methionine-γ-lyase producers, activity of this enzyme, obtained from various sources, and information on tumor models and cell cultures, showing methionine dependence are summarised. |
| format | Article |
| id | doaj-art-b5d3ccb1f94a44d386a0bd4589c3aecd |
| institution | DOAJ |
| issn | 1997-6933 2500-2139 |
| language | Russian |
| publishDate | 2017-07-01 |
| publisher | Practical Medicine Publishing House |
| record_format | Article |
| series | Клиническая онкогематология |
| spelling | doaj-art-b5d3ccb1f94a44d386a0bd4589c3aecd2025-08-20T03:20:55ZrusPractical Medicine Publishing HouseКлиническая онкогематология1997-69332500-21392017-07-0110332433210.21320/2500-2139-2017-10-3-324-332Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor TherapyVS Pokrovskii0DZh Davydov1NV Anufrieva2DD Zhdanov3EM Treshchalina4TV Demidkina5EA Morozova6NN Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478NN Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478VA Engelhardt Institute of Molecular Biology, 32 Vavilova str., Moscow, Russian Federation, 119991VN Orekhovich Institute of Biomedical Chemistry, 10 bld. 8 Pogodinskaya str., Moscow, Russian Federation, 119121NN Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478VA Engelhardt Institute of Molecular Biology, 32 Vavilova str., Moscow, Russian Federation, 119991VA Engelhardt Institute of Molecular Biology, 32 Vavilova str., Moscow, Russian Federation, 119991This review presents the characteristics of the cellular metabolism of methionine, as well as known data on the mechanisms of the development of methionine dependence in malignant cells. The possibilities of using a non-methionine diet for the control of the tumor growth in patients with various forms of cancer are considered. The newest information about methionine-γ-lyase, an enzyme providing elimination of methionine from plasma, is grouped and summarised. Its role as a potential antitumor enzyme is disclosed. Data on methionine-γ-lyase producers, activity of this enzyme, obtained from various sources, and information on tumor models and cell cultures, showing methionine dependence are summarised.http://bloodjournal.ru/wp-content/uploads/2017/09/4.pdfmethionine-γ-liasemethioninemethionine dependencycancer cellscanceranticancer enzymesantitumor therapy |
| spellingShingle | VS Pokrovskii DZh Davydov NV Anufrieva DD Zhdanov EM Treshchalina TV Demidkina EA Morozova Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy Клиническая онкогематология methionine-γ-liase methionine methionine dependency cancer cells cancer anticancer enzymes antitumor therapy |
| title | Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy |
| title_full | Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy |
| title_fullStr | Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy |
| title_full_unstemmed | Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy |
| title_short | Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy |
| title_sort | pathological metabolism of methionine in malignant cells is a potential target for the antitumor therapy |
| topic | methionine-γ-liase methionine methionine dependency cancer cells cancer anticancer enzymes antitumor therapy |
| url | http://bloodjournal.ru/wp-content/uploads/2017/09/4.pdf |
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