The role of the microbiome on immune homeostasis of the host nervous system
The gut microbiota is often termed the “second genome” of the human body. It has been shown to be one of the most significant environmental factors (non-genetic) influencing the onset, progression, and prognosis of various neurological and psychiatric disorders through its interactions with the host...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609960/full |
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| author | Shaojuan Zhao Danlei Fu Yin Lin Xiaoya Sun Xiaokang Wang Xuanzhen Wu Xuejiao Zhang |
| author_facet | Shaojuan Zhao Danlei Fu Yin Lin Xiaoya Sun Xiaokang Wang Xuanzhen Wu Xuejiao Zhang |
| author_sort | Shaojuan Zhao |
| collection | DOAJ |
| description | The gut microbiota is often termed the “second genome” of the human body. It has been shown to be one of the most significant environmental factors (non-genetic) influencing the onset, progression, and prognosis of various neurological and psychiatric disorders through its interactions with the host immune, nervous, and endocrine systems. Changes in the function and composition of the gut microbiota are strongly associated with amyotrophic lateral sclerosis, autism spectrum disorder, depression, Parkinson’s disease, and Alzheimer’s disease. This review summarizes the research regarding the associations and regulatory mechanisms between the gut microbiota and the central nervous system in order to explore the role of the gut microbiota in maintaining neural homeostasis. |
| format | Article |
| id | doaj-art-b5d2cc335b3546a6af4b16bb1f8e93f7 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b5d2cc335b3546a6af4b16bb1f8e93f72025-08-20T02:46:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16099601609960The role of the microbiome on immune homeostasis of the host nervous systemShaojuan Zhao0Danlei Fu1Yin Lin2Xiaoya Sun3Xiaokang Wang4Xuanzhen Wu5Xuejiao Zhang6Shenzhen Futian Third People’s Hospital, Shenzhen, ChinaMedical School, Shenzhen University, Shenzhen, ChinaShenzhen Futian Third People’s Hospital, Shenzhen, ChinaShenzhen Futian Third People’s Hospital, Shenzhen, ChinaShenzhen Longhua District Central Hospital, Shenzhen, ChinaShenzhen Futian Third People’s Hospital, Shenzhen, ChinaShenzhen Futian Third People’s Hospital, Shenzhen, ChinaThe gut microbiota is often termed the “second genome” of the human body. It has been shown to be one of the most significant environmental factors (non-genetic) influencing the onset, progression, and prognosis of various neurological and psychiatric disorders through its interactions with the host immune, nervous, and endocrine systems. Changes in the function and composition of the gut microbiota are strongly associated with amyotrophic lateral sclerosis, autism spectrum disorder, depression, Parkinson’s disease, and Alzheimer’s disease. This review summarizes the research regarding the associations and regulatory mechanisms between the gut microbiota and the central nervous system in order to explore the role of the gut microbiota in maintaining neural homeostasis.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609960/fullgut microbiotamicrogliamicrobiota-gut-brain axisaromatic compoundsneuroinflammation |
| spellingShingle | Shaojuan Zhao Danlei Fu Yin Lin Xiaoya Sun Xiaokang Wang Xuanzhen Wu Xuejiao Zhang The role of the microbiome on immune homeostasis of the host nervous system Frontiers in Immunology gut microbiota microglia microbiota-gut-brain axis aromatic compounds neuroinflammation |
| title | The role of the microbiome on immune homeostasis of the host nervous system |
| title_full | The role of the microbiome on immune homeostasis of the host nervous system |
| title_fullStr | The role of the microbiome on immune homeostasis of the host nervous system |
| title_full_unstemmed | The role of the microbiome on immune homeostasis of the host nervous system |
| title_short | The role of the microbiome on immune homeostasis of the host nervous system |
| title_sort | role of the microbiome on immune homeostasis of the host nervous system |
| topic | gut microbiota microglia microbiota-gut-brain axis aromatic compounds neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609960/full |
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