Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise
Objective: To investigate whether there is a difference in hardness and hemoglobin concentration changes in the infrapatellar fat pad (IFP) during isometric quadriceps exercise (IQE) in patients with knee osteoarthritis (KOA) between those with and without knee extension limitation. Design: In this...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124001262 |
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| author | Syoya Nakanishi Masahiro Tsutsumi Takashi Kitagawa Toshinori Miyashita Makoto Wada Shintarou Kudo |
| author_facet | Syoya Nakanishi Masahiro Tsutsumi Takashi Kitagawa Toshinori Miyashita Makoto Wada Shintarou Kudo |
| author_sort | Syoya Nakanishi |
| collection | DOAJ |
| description | Objective: To investigate whether there is a difference in hardness and hemoglobin concentration changes in the infrapatellar fat pad (IFP) during isometric quadriceps exercise (IQE) in patients with knee osteoarthritis (KOA) between those with and without knee extension limitation. Design: In this cross-sectional study, data were collected at an orthopedic clinic from March 2022 to April 2023. Among patients diagnosed with KOA, those with knee joint extension range of motion <0° and >0° were defined as the limited group (n = 16) and non-limited group (n = 13), respectively. Ultrasonography was performed at rest and during IQE to measure IFP hardness based on shear wave velocity. Near-infrared spectroscopy was performed to measure oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), and total hemoglobin (cHb) in the IFP before (baseline), during (IQE task), and post IQE. IFP hardness and O2Hb, HHb, and cHb concentration were analyzed using a linear mixed model for the groups and measurement points. Results: IFP hardness changes during IQE were significantly less in the limited group than in the non-limited group (limited: mean difference [MD] = −0.136, 95 % confidence interval [CI] [−0.475, 0.203]; non-limited: MD = −1.154, 95 % CI [−1.530, −0.778]). O2Hb concentration did not significantly change at post compared with baseline in the limited group but did in the non-limited group (limited: MD = −0.024, 95 % CI [−0.961, 0.913]; non-limited: MD = −4.118, 95 % CI [−5.156, −3.079]). Conclusions: The limited group revealed no IFP hardness and hemoglobin concentration change following IQE, whereas the opposite was observed for the non-limited group, indicating oxygenation. |
| format | Article |
| id | doaj-art-b5d0cd431c0141609deebcfee283cc68 |
| institution | OA Journals |
| issn | 2665-9131 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-b5d0cd431c0141609deebcfee283cc682025-08-20T02:01:01ZengElsevierOsteoarthritis and Cartilage Open2665-91312025-03-017110055910.1016/j.ocarto.2024.100559Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exerciseSyoya Nakanishi0Masahiro Tsutsumi1Takashi Kitagawa2Toshinori Miyashita3Makoto Wada4Shintarou Kudo5Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; Wada Orthopaedic Clinic, Osaka, JapanGraduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; Inclusive Medical Sciences Research Institute, Morinomiya University of Medical Sciences, Osaka, JapanGraduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; Department of Rehabilitation, Higashiosaka Hospital, Osaka, JapanInclusive Medical Sciences Research Institute, Morinomiya University of Medical Sciences, Osaka, Japan; Osaka Bay Clinic, Morinomiya University of Medical Sciences, Osaka, JapanWada Orthopaedic Clinic, Osaka, JapanGraduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; Inclusive Medical Sciences Research Institute, Morinomiya University of Medical Sciences, Osaka, Japan; AR-Ex Medical Research Center, Tokyo, Japan; Corresponding author. Morinomiya University of Medical Sciences, 1-26-16 Nankokita, Suminoe ku, Osaka, Osaka 559-8611, Japan.Objective: To investigate whether there is a difference in hardness and hemoglobin concentration changes in the infrapatellar fat pad (IFP) during isometric quadriceps exercise (IQE) in patients with knee osteoarthritis (KOA) between those with and without knee extension limitation. Design: In this cross-sectional study, data were collected at an orthopedic clinic from March 2022 to April 2023. Among patients diagnosed with KOA, those with knee joint extension range of motion <0° and >0° were defined as the limited group (n = 16) and non-limited group (n = 13), respectively. Ultrasonography was performed at rest and during IQE to measure IFP hardness based on shear wave velocity. Near-infrared spectroscopy was performed to measure oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), and total hemoglobin (cHb) in the IFP before (baseline), during (IQE task), and post IQE. IFP hardness and O2Hb, HHb, and cHb concentration were analyzed using a linear mixed model for the groups and measurement points. Results: IFP hardness changes during IQE were significantly less in the limited group than in the non-limited group (limited: mean difference [MD] = −0.136, 95 % confidence interval [CI] [−0.475, 0.203]; non-limited: MD = −1.154, 95 % CI [−1.530, −0.778]). O2Hb concentration did not significantly change at post compared with baseline in the limited group but did in the non-limited group (limited: MD = −0.024, 95 % CI [−0.961, 0.913]; non-limited: MD = −4.118, 95 % CI [−5.156, −3.079]). Conclusions: The limited group revealed no IFP hardness and hemoglobin concentration change following IQE, whereas the opposite was observed for the non-limited group, indicating oxygenation.http://www.sciencedirect.com/science/article/pii/S2665913124001262Knee osteoarthritisOsteoarthritisInfrapatellar fat padIsometric quadriceps exerciseKnee joint extension limitationHemoglobin |
| spellingShingle | Syoya Nakanishi Masahiro Tsutsumi Takashi Kitagawa Toshinori Miyashita Makoto Wada Shintarou Kudo Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise Osteoarthritis and Cartilage Open Knee osteoarthritis Osteoarthritis Infrapatellar fat pad Isometric quadriceps exercise Knee joint extension limitation Hemoglobin |
| title | Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise |
| title_full | Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise |
| title_fullStr | Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise |
| title_full_unstemmed | Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise |
| title_short | Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise |
| title_sort | knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise |
| topic | Knee osteoarthritis Osteoarthritis Infrapatellar fat pad Isometric quadriceps exercise Knee joint extension limitation Hemoglobin |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124001262 |
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