MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS
Aim. To investigate the effects of serotonin on duodenal motor activity. Materials and Methods. Experiments were performed on Wistar rats (n=83) which received nembutal anesthesia. We further conducted electromyography and measured hydrostatic pressure in the duodenum. Results. Intraarterial adminis...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2018-06-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/86 |
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| author | VIKTOR M. Smirnov DMITRIY S. Sveshnikov ANDREY V. Kuchuk TATIANA E. Kuznetsova ELENA D. Ignatova LARISA V. Trubetskaya |
| author_facet | VIKTOR M. Smirnov DMITRIY S. Sveshnikov ANDREY V. Kuchuk TATIANA E. Kuznetsova ELENA D. Ignatova LARISA V. Trubetskaya |
| author_sort | VIKTOR M. Smirnov |
| collection | DOAJ |
| description | Aim. To investigate the effects of serotonin on duodenal motor activity. Materials and Methods. Experiments were performed on Wistar rats (n=83) which received nembutal anesthesia. We further conducted electromyography and measured hydrostatic pressure in the duodenum. Results. Intraarterial administration of 0.05 mg/kg, 0.1 mg/kg, and 0.15 mg/kg serotonin induced inhibitory responses in 29%, 8.3%, and 6.3% of rats, respectively. Other rats, however, showed stimulatory responses or no specific response. Intravenous administration of serotonin did not enhance bowel contractions. Conclusion. Inhibitory responses occurred at low doses of serotonin due to the activation of presynaptic5-hydroxytryptamine (5-HT, serotonin) receptors while stimulatory responses were induced by high doses of serotonin through muscular 5-HT receptors. |
| format | Article |
| id | doaj-art-b5cf5d1f8f7c4123bd26ed8ff03894b9 |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2018-06-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-b5cf5d1f8f7c4123bd26ed8ff03894b92025-08-20T03:42:38ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412018-06-013261185MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONSVIKTOR M. Smirnov0DMITRIY S. Sveshnikov1ANDREY V. Kuchuk2TATIANA E. Kuznetsova3ELENA D. Ignatova4LARISA V. Trubetskaya5Pirogov Russian National Research Medical UniversityPeoples' Friendship University of RussiaPeoples' Friendship University of RussiaPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityAim. To investigate the effects of serotonin on duodenal motor activity. Materials and Methods. Experiments were performed on Wistar rats (n=83) which received nembutal anesthesia. We further conducted electromyography and measured hydrostatic pressure in the duodenum. Results. Intraarterial administration of 0.05 mg/kg, 0.1 mg/kg, and 0.15 mg/kg serotonin induced inhibitory responses in 29%, 8.3%, and 6.3% of rats, respectively. Other rats, however, showed stimulatory responses or no specific response. Intravenous administration of serotonin did not enhance bowel contractions. Conclusion. Inhibitory responses occurred at low doses of serotonin due to the activation of presynaptic5-hydroxytryptamine (5-HT, serotonin) receptors while stimulatory responses were induced by high doses of serotonin through muscular 5-HT receptors.https://fcm.kemsmu.ru/jour/article/view/86двенадцатиперстная кишкамоторикарегуляциясеротонинduodenummotor activityregulationserotonin |
| spellingShingle | VIKTOR M. Smirnov DMITRIY S. Sveshnikov ANDREY V. Kuchuk TATIANA E. Kuznetsova ELENA D. Ignatova LARISA V. Trubetskaya MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS Фундаментальная и клиническая медицина двенадцатиперстная кишка моторика регуляция серотонин duodenum motor activity regulation serotonin |
| title | MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS |
| title_full | MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS |
| title_fullStr | MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS |
| title_full_unstemmed | MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS |
| title_short | MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS |
| title_sort | mechanism of inhibitory and stimulatory effects of serotonin on duodenal contractions |
| topic | двенадцатиперстная кишка моторика регуляция серотонин duodenum motor activity regulation serotonin |
| url | https://fcm.kemsmu.ru/jour/article/view/86 |
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