Nystagmus as the presenting sign of thrombotic thrombocytopenic purpura
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease which can initially present with predominant ocular symptoms. We report the case of a 21-year-old female patient with a complaint of acute onset of bilateral blurry vision. An eye exam showed a bilateral horizontal nystagm...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | The Pan-American Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/pajo.pajo_26_25 |
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| author | Iatissam El Belhadji Adil Mchachi Mohamed Elbelhadji |
| author_facet | Iatissam El Belhadji Adil Mchachi Mohamed Elbelhadji |
| author_sort | Iatissam El Belhadji |
| collection | DOAJ |
| description | Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease which can initially present with predominant ocular symptoms. We report the case of a 21-year-old female patient with a complaint of acute onset of bilateral blurry vision. An eye exam showed a bilateral horizontal nystagmus, and her best-corrected visual acuity (BCVA) was hand movement. Fundus examination showed bilateral serous retinal detachment (SRD), and bilateral papillary edema. Retinal angiography and optical coherence tomography (OCT) later confirmed the SRD. She was diagnosed with TTP and was treated systemically with frozen plasma, oral prednisone, and calcium channel blockers. At her first follow-up visit, her BCVA had improved to 20/100; fundus examination and OCT confirmed the partial resolution of bilateral macular SRD. TTP should be considered in patients presenting with an association of SRD and any other ocular signs. Fast, appropriate systemic treatment is mandatory as it is a life-threatening disease, and to assure a satisfying visual outcome. |
| format | Article |
| id | doaj-art-b5cc8c08807541e489fb2b111c604917 |
| institution | DOAJ |
| issn | 2666-4909 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Pan-American Journal of Ophthalmology |
| spelling | doaj-art-b5cc8c08807541e489fb2b111c6049172025-08-20T02:42:45ZengWolters Kluwer Medknow PublicationsThe Pan-American Journal of Ophthalmology2666-49092025-06-017116016010.4103/pajo.pajo_26_25Nystagmus as the presenting sign of thrombotic thrombocytopenic purpuraIatissam El BelhadjiAdil MchachiMohamed ElbelhadjiThrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease which can initially present with predominant ocular symptoms. We report the case of a 21-year-old female patient with a complaint of acute onset of bilateral blurry vision. An eye exam showed a bilateral horizontal nystagmus, and her best-corrected visual acuity (BCVA) was hand movement. Fundus examination showed bilateral serous retinal detachment (SRD), and bilateral papillary edema. Retinal angiography and optical coherence tomography (OCT) later confirmed the SRD. She was diagnosed with TTP and was treated systemically with frozen plasma, oral prednisone, and calcium channel blockers. At her first follow-up visit, her BCVA had improved to 20/100; fundus examination and OCT confirmed the partial resolution of bilateral macular SRD. TTP should be considered in patients presenting with an association of SRD and any other ocular signs. Fast, appropriate systemic treatment is mandatory as it is a life-threatening disease, and to assure a satisfying visual outcome.https://journals.lww.com/10.4103/pajo.pajo_26_25arterial hypertensionhypertensive retinopathynystagmusoptic neuritispapillary edemarenal failureretinal detachmentthrombotic microangiopathythrombotic thrombocytopenic purpura |
| spellingShingle | Iatissam El Belhadji Adil Mchachi Mohamed Elbelhadji Nystagmus as the presenting sign of thrombotic thrombocytopenic purpura The Pan-American Journal of Ophthalmology arterial hypertension hypertensive retinopathy nystagmus optic neuritis papillary edema renal failure retinal detachment thrombotic microangiopathy thrombotic thrombocytopenic purpura |
| title | Nystagmus as the presenting sign of thrombotic thrombocytopenic purpura |
| title_full | Nystagmus as the presenting sign of thrombotic thrombocytopenic purpura |
| title_fullStr | Nystagmus as the presenting sign of thrombotic thrombocytopenic purpura |
| title_full_unstemmed | Nystagmus as the presenting sign of thrombotic thrombocytopenic purpura |
| title_short | Nystagmus as the presenting sign of thrombotic thrombocytopenic purpura |
| title_sort | nystagmus as the presenting sign of thrombotic thrombocytopenic purpura |
| topic | arterial hypertension hypertensive retinopathy nystagmus optic neuritis papillary edema renal failure retinal detachment thrombotic microangiopathy thrombotic thrombocytopenic purpura |
| url | https://journals.lww.com/10.4103/pajo.pajo_26_25 |
| work_keys_str_mv | AT iatissamelbelhadji nystagmusasthepresentingsignofthromboticthrombocytopenicpurpura AT adilmchachi nystagmusasthepresentingsignofthromboticthrombocytopenicpurpura AT mohamedelbelhadji nystagmusasthepresentingsignofthromboticthrombocytopenicpurpura |