New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels
The PalmLab glucometer is a newly designed plasma separation glucose oxidase (GO)-based glucometer. Past studies have shown that the accuracy of GO-based glucometers is compromised when measurements are taken in patients with high PO2 levels. We performed a two-arm study comparing the fitness of the...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-02-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957210000161 |
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| author | Ming-Sheng Lee Lon-Yen Tsao Yu-Ching Tseng Shiu-Jung Tsai Mei-Li Tsai Tony Huang Han-Yao Chiu |
| author_facet | Ming-Sheng Lee Lon-Yen Tsao Yu-Ching Tseng Shiu-Jung Tsai Mei-Li Tsai Tony Huang Han-Yao Chiu |
| author_sort | Ming-Sheng Lee |
| collection | DOAJ |
| description | The PalmLab glucometer is a newly designed plasma separation glucose oxidase (GO)-based glucometer. Past studies have shown that the accuracy of GO-based glucometers is compromised when measurements are taken in patients with high PO2 levels. We performed a two-arm study comparing the fitness of the PalmLab blood glucometer with that of a standard glucose analyzer in monitoring blood glucose levels in pediatric patients, especially when arterial partial pressure of oxygen (PO2) was high.
Methods: In the first arm of the study, arterial blood samples from pediatric patients were measured by the PalmLab blood glucometer and the YSI 2302 Plus Glucose/Lactate analyzer. In the second arm of the study, venous blood samples from adult volunteers were spiked with glucose water to prepare three different levels of glucose (65, 150, and 300 mg/dL) and then oxygenated to six levels of PO2 (range, 40–400 mmHg). The biases of the PalmLab glucometer were calculated.
Results: A total of 162 samples were collected in the first arm of the study. Results of linear regression showed that the coefficient of determination (R2) between PalmLab glucometer and standard glucose analyzer was 0.9864. Error grid analysis revealed that all the results were within Zone A (clinically accurate estimate zone). The biases between the two systems were low at different PO2 levels. In the second arm of the study, the results were also unaffected by changes in PO2.
Conclusion: The PalmLab glucometer provides accurate results in samples with high PO2 and is suitable for measuring arterial glucose levels in pediatric patients. |
| format | Article |
| id | doaj-art-b5c7e1a57a8a483582237060fdfb10b0 |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2011-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-b5c7e1a57a8a483582237060fdfb10b02025-08-20T03:05:07ZengElsevierPediatrics and Neonatology1875-95722011-02-01521242910.1016/j.pedneo.2010.12.008New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 LevelsMing-Sheng Lee0Lon-Yen Tsao1Yu-Ching Tseng2Shiu-Jung Tsai3Mei-Li Tsai4Tony Huang5Han-Yao Chiu6Department of Pediatric Critical Care Medicine, Changhua Christian Hospital, Changhua, TaiwanDepartment of Neonatal Medicine, Changhua Christian Hospital, Changhua, TaiwanDepartment of Pediatric Emergency Medicine, Changhua Christian Hospital, Changhua, TaiwanPediatric Respiratory Therapeutic Unit, Changhua Christian Hospital, Changhua, TaiwanPediatric Intensive Care Unit, Changhua Christian Hospital, Changhua, TaiwanSand County Biotechnology Inc, Hsinchu, TaiwanDepartment of Pediatric Critical Care Medicine, Changhua Christian Hospital, Changhua, TaiwanThe PalmLab glucometer is a newly designed plasma separation glucose oxidase (GO)-based glucometer. Past studies have shown that the accuracy of GO-based glucometers is compromised when measurements are taken in patients with high PO2 levels. We performed a two-arm study comparing the fitness of the PalmLab blood glucometer with that of a standard glucose analyzer in monitoring blood glucose levels in pediatric patients, especially when arterial partial pressure of oxygen (PO2) was high. Methods: In the first arm of the study, arterial blood samples from pediatric patients were measured by the PalmLab blood glucometer and the YSI 2302 Plus Glucose/Lactate analyzer. In the second arm of the study, venous blood samples from adult volunteers were spiked with glucose water to prepare three different levels of glucose (65, 150, and 300 mg/dL) and then oxygenated to six levels of PO2 (range, 40–400 mmHg). The biases of the PalmLab glucometer were calculated. Results: A total of 162 samples were collected in the first arm of the study. Results of linear regression showed that the coefficient of determination (R2) between PalmLab glucometer and standard glucose analyzer was 0.9864. Error grid analysis revealed that all the results were within Zone A (clinically accurate estimate zone). The biases between the two systems were low at different PO2 levels. In the second arm of the study, the results were also unaffected by changes in PO2. Conclusion: The PalmLab glucometer provides accurate results in samples with high PO2 and is suitable for measuring arterial glucose levels in pediatric patients.http://www.sciencedirect.com/science/article/pii/S1875957210000161childglucometerglucose oxidasepartial pressure of oxygenplasma separation |
| spellingShingle | Ming-Sheng Lee Lon-Yen Tsao Yu-Ching Tseng Shiu-Jung Tsai Mei-Li Tsai Tony Huang Han-Yao Chiu New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels Pediatrics and Neonatology child glucometer glucose oxidase partial pressure of oxygen plasma separation |
| title | New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels |
| title_full | New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels |
| title_fullStr | New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels |
| title_full_unstemmed | New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels |
| title_short | New Plasma Separation Glucose Oxidase-based Glucometer in Monitoring of Blood With Different PO2 Levels |
| title_sort | new plasma separation glucose oxidase based glucometer in monitoring of blood with different po2 levels |
| topic | child glucometer glucose oxidase partial pressure of oxygen plasma separation |
| url | http://www.sciencedirect.com/science/article/pii/S1875957210000161 |
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