Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril
ACE inhibitors, with their proven beneficial effect on survival, are widely used for treating patients after myocardial infarction (MI). After MI, these agents prevent disadaptive heart and vessel remodelling. The magnitude of ACE inhibitors' cardioprotective and vasculoprotective effects depen...
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| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1690 |
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| author | G. K. Кiyakbaev |
| author_facet | G. K. Кiyakbaev |
| author_sort | G. K. Кiyakbaev |
| collection | DOAJ |
| description | ACE inhibitors, with their proven beneficial effect on survival, are widely used for treating patients after myocardial infarction (MI). After MI, these agents prevent disadaptive heart and vessel remodelling. The magnitude of ACE inhibitors' cardioprotective and vasculoprotective effects depends on their impact on tissue renin-angiotensin-aldosterone system. As a part of a wide-scale SMILE project, it has been demonstrated that zofenopril, due to its high antioxidant activity and myocardial and vascular tissue penetrant ability, is effective and safe in patients with anterior MI, who have stable hemodynamics and do not receive thrombolytic therapy, regardless of patients' age, myocardial damage size, presence or absence of arterial hypertension and/or heart failure. Clinical evidence had been obtained on antihypertensive-independent anti-ischemic effect of zofenopril, which is known to be one of key cardioprotection mechanisms. |
| format | Article |
| id | doaj-art-b5c42215ebe74de09cda86a5b1f59660 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2008-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-b5c42215ebe74de09cda86a5b1f596602025-08-20T03:21:39Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-12-01771191271408Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenoprilG. K. Кiyakbaev0Russian University of People's Friendship. MoscowACE inhibitors, with their proven beneficial effect on survival, are widely used for treating patients after myocardial infarction (MI). After MI, these agents prevent disadaptive heart and vessel remodelling. The magnitude of ACE inhibitors' cardioprotective and vasculoprotective effects depends on their impact on tissue renin-angiotensin-aldosterone system. As a part of a wide-scale SMILE project, it has been demonstrated that zofenopril, due to its high antioxidant activity and myocardial and vascular tissue penetrant ability, is effective and safe in patients with anterior MI, who have stable hemodynamics and do not receive thrombolytic therapy, regardless of patients' age, myocardial damage size, presence or absence of arterial hypertension and/or heart failure. Clinical evidence had been obtained on antihypertensive-independent anti-ischemic effect of zofenopril, which is known to be one of key cardioprotection mechanisms.https://cardiovascular.elpub.ru/jour/article/view/1690асе inhibitorsmyocardial infarctionsulphydryl grouplipophylic qualitieszofenopril |
| spellingShingle | G. K. Кiyakbaev Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril Кардиоваскулярная терапия и профилактика асе inhibitors myocardial infarction sulphydryl group lipophylic qualities zofenopril |
| title | Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril |
| title_full | Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril |
| title_fullStr | Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril |
| title_full_unstemmed | Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril |
| title_short | Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril |
| title_sort | clinical role of cardioprotective and vasculoprotective effects of асе inhibitors in myocardial infarction zofenopril |
| topic | асе inhibitors myocardial infarction sulphydryl group lipophylic qualities zofenopril |
| url | https://cardiovascular.elpub.ru/jour/article/view/1690 |
| work_keys_str_mv | AT gkkiyakbaev clinicalroleofcardioprotectiveandvasculoprotectiveeffectsofaseinhibitorsinmyocardialinfarctionzofenopril |