Development and optimization of the activated charcoal suspension composition based on a mixture design approach
In this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were optimized using a mixture design approach. The adsorption power of the activated charcoal suspension was selected as the critical quality attribute...
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| Format: | Article |
| Language: | English |
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Sciendo
2015-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2015-0005 |
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| _version_ | 1832569684612874240 |
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| author | Ronowicz Joanna Kupcewicz Bogumiła Pałkowski Łukasz Krysiński Jerzy |
| author_facet | Ronowicz Joanna Kupcewicz Bogumiła Pałkowski Łukasz Krysiński Jerzy |
| author_sort | Ronowicz Joanna |
| collection | DOAJ |
| description | In this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were optimized using a mixture design approach. The adsorption power of the activated charcoal suspension was selected as the critical quality attribute influencing the efficacy of medical treatment. Significant prognostic models (p < 0.05) were obtained to describe in detail the interrelations between excipient levels and the adsorption power of the formulation. Liquid flavour had a critical impact on the adsorption power of the suspension. Formulations containing the largest amount of liquid flavour showed the lowest adsorption power. Sorbitol was not adsorbed onto activated charcoal so strongly as liquid flavour. A slight increase in the content of carboxymethylcellulose sodium led to a marked decrease in adsorption power. The obtained mathematical models and response surface allowed selection of the optimal composition of excipients in a final drug product |
| format | Article |
| id | doaj-art-b5bd6a5f941544058e6a12486b26b2fc |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-b5bd6a5f941544058e6a12486b26b2fc2025-02-02T19:57:23ZengSciendoActa Pharmaceutica1846-95582015-03-01651839010.1515/acph-2015-0005acph-2015-0005Development and optimization of the activated charcoal suspension composition based on a mixture design approachRonowicz Joanna0Kupcewicz Bogumiła1Pałkowski Łukasz2Krysiński Jerzy3Department of Inorganic and Analytical Chemistry Faculty of Pharmacy Collegium Medicum Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, PolandDepartment of Inorganic and Analytical Chemistry Faculty of Pharmacy Collegium Medicum Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, PolandDepartment of Pharmaceutical Technology Faculty of Pharmacy Collegium Medicum Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, PolandDepartment of Pharmaceutical Technology Faculty of Pharmacy Collegium Medicum Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, PolandIn this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were optimized using a mixture design approach. The adsorption power of the activated charcoal suspension was selected as the critical quality attribute influencing the efficacy of medical treatment. Significant prognostic models (p < 0.05) were obtained to describe in detail the interrelations between excipient levels and the adsorption power of the formulation. Liquid flavour had a critical impact on the adsorption power of the suspension. Formulations containing the largest amount of liquid flavour showed the lowest adsorption power. Sorbitol was not adsorbed onto activated charcoal so strongly as liquid flavour. A slight increase in the content of carboxymethylcellulose sodium led to a marked decrease in adsorption power. The obtained mathematical models and response surface allowed selection of the optimal composition of excipients in a final drug producthttps://doi.org/10.1515/acph-2015-0005activated charcoaladsorption powerphenazoneexperimental designquality by design concept |
| spellingShingle | Ronowicz Joanna Kupcewicz Bogumiła Pałkowski Łukasz Krysiński Jerzy Development and optimization of the activated charcoal suspension composition based on a mixture design approach Acta Pharmaceutica activated charcoal adsorption power phenazone experimental design quality by design concept |
| title | Development and optimization of the activated charcoal suspension composition based on a mixture design approach |
| title_full | Development and optimization of the activated charcoal suspension composition based on a mixture design approach |
| title_fullStr | Development and optimization of the activated charcoal suspension composition based on a mixture design approach |
| title_full_unstemmed | Development and optimization of the activated charcoal suspension composition based on a mixture design approach |
| title_short | Development and optimization of the activated charcoal suspension composition based on a mixture design approach |
| title_sort | development and optimization of the activated charcoal suspension composition based on a mixture design approach |
| topic | activated charcoal adsorption power phenazone experimental design quality by design concept |
| url | https://doi.org/10.1515/acph-2015-0005 |
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