Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China
ObjectiveThis study aimed to clarify the demographics, evaluate risk factors associated with malignant progression, and assess pregnancy outcomes among patients with hydatidiform mole (HM) using a large, retrospective cohort study in Shanghai.MethodsThis retrospective cohort study included patients...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1643590/full |
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| author | Tingting Zhu Tingting Zhu Tingting Zhu Guohua Zhu Guohua Zhu Guohua Zhu Jiahui Ma Jiahui Ma Jiahui Ma Xiaojuan Yu Xiaojuan Yu Xiaojuan Yu Tingting Chen Tingting Chen Tingting Chen Xiang Tao Xiang Tao Xiang Tao Li Sun Li Sun Li Sun Xin Lu Xin Lu Xin Lu Yan Du Yan Du Yan Du |
| author_facet | Tingting Zhu Tingting Zhu Tingting Zhu Guohua Zhu Guohua Zhu Guohua Zhu Jiahui Ma Jiahui Ma Jiahui Ma Xiaojuan Yu Xiaojuan Yu Xiaojuan Yu Tingting Chen Tingting Chen Tingting Chen Xiang Tao Xiang Tao Xiang Tao Li Sun Li Sun Li Sun Xin Lu Xin Lu Xin Lu Yan Du Yan Du Yan Du |
| author_sort | Tingting Zhu |
| collection | DOAJ |
| description | ObjectiveThis study aimed to clarify the demographics, evaluate risk factors associated with malignant progression, and assess pregnancy outcomes among patients with hydatidiform mole (HM) using a large, retrospective cohort study in Shanghai.MethodsThis retrospective cohort study included patients with pathologically confirmed HM from 2019 to 2023. Descriptive analyses were performed to describe the demographic characteristics, progression to postmolar gestational trophoblastic neoplasia (pGTN), and reproductive outcomes of patients. Univariate and multivariate logistic regression analyses were conducted to evaluate risk factors and develop predictive models for pGTN.ResultsOf 506 patients with HM, the average age and gestational age at diagnosis were approximately 33 years and 10 weeks, respectively. During follow-up, 42 patients (8.3%) progressed to pGTN, all achieved complete response after treatment. Univariate and multivariate analyses revealed that significant risk factors for progression to pGTN included pathological type and maximum diameter of lesions by ultrasound pre-evacuation (p < 0.05 for both). A predictive model incorporating age, β-hCG ratio (before/after evacuation), and ultrasound characteristics (uterine/lesion ratio) demonstrated optimal performance and goodness of fit. Among the 304 patients who intended to conceive, 254 had documented reproductive outcomes (follow-up rate: 83.6%). Of these, 163 patients (64.2%) achieved successful re-pregnancy, including 131 (80.4%) livebirths.ConclusionOur study provides a comprehensive update on the demographics, risk factors associated with progression to pGTN, and reproductive outcomes of patients with HM in Shanghai. The clinical application of the predictive model needs to be further verified in a longitudinal setting. |
| format | Article |
| id | doaj-art-b5bacb896b364bc4bb5ef7cee69a2d5e |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-b5bacb896b364bc4bb5ef7cee69a2d5e2025-08-20T02:46:02ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.16435901643590Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, ChinaTingting Zhu0Tingting Zhu1Tingting Zhu2Guohua Zhu3Guohua Zhu4Guohua Zhu5Jiahui Ma6Jiahui Ma7Jiahui Ma8Xiaojuan Yu9Xiaojuan Yu10Xiaojuan Yu11Tingting Chen12Tingting Chen13Tingting Chen14Xiang Tao15Xiang Tao16Xiang Tao17Li Sun18Li Sun19Li Sun20Xin Lu21Xin Lu22Xin Lu23Yan Du24Yan Du25Yan Du26Department of Gynecology Oncology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaDepartment of Gynecology Oncology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaClinical Research Unit, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaClinical Research Unit, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaDepartment of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaDepartment of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaDepartment of Ultrasound, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Gynecology Oncology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaShanghai Key Lab of Reproduction and Development, Shanghai, ChinaShanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaClinical Research Unit, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaObjectiveThis study aimed to clarify the demographics, evaluate risk factors associated with malignant progression, and assess pregnancy outcomes among patients with hydatidiform mole (HM) using a large, retrospective cohort study in Shanghai.MethodsThis retrospective cohort study included patients with pathologically confirmed HM from 2019 to 2023. Descriptive analyses were performed to describe the demographic characteristics, progression to postmolar gestational trophoblastic neoplasia (pGTN), and reproductive outcomes of patients. Univariate and multivariate logistic regression analyses were conducted to evaluate risk factors and develop predictive models for pGTN.ResultsOf 506 patients with HM, the average age and gestational age at diagnosis were approximately 33 years and 10 weeks, respectively. During follow-up, 42 patients (8.3%) progressed to pGTN, all achieved complete response after treatment. Univariate and multivariate analyses revealed that significant risk factors for progression to pGTN included pathological type and maximum diameter of lesions by ultrasound pre-evacuation (p < 0.05 for both). A predictive model incorporating age, β-hCG ratio (before/after evacuation), and ultrasound characteristics (uterine/lesion ratio) demonstrated optimal performance and goodness of fit. Among the 304 patients who intended to conceive, 254 had documented reproductive outcomes (follow-up rate: 83.6%). Of these, 163 patients (64.2%) achieved successful re-pregnancy, including 131 (80.4%) livebirths.ConclusionOur study provides a comprehensive update on the demographics, risk factors associated with progression to pGTN, and reproductive outcomes of patients with HM in Shanghai. The clinical application of the predictive model needs to be further verified in a longitudinal setting.https://www.frontiersin.org/articles/10.3389/fonc.2025.1643590/fullhydatidiform moledemographicspostmolar gestational trophoblastic neoplasiarisk factorpregnancy outcome |
| spellingShingle | Tingting Zhu Tingting Zhu Tingting Zhu Guohua Zhu Guohua Zhu Guohua Zhu Jiahui Ma Jiahui Ma Jiahui Ma Xiaojuan Yu Xiaojuan Yu Xiaojuan Yu Tingting Chen Tingting Chen Tingting Chen Xiang Tao Xiang Tao Xiang Tao Li Sun Li Sun Li Sun Xin Lu Xin Lu Xin Lu Yan Du Yan Du Yan Du Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China Frontiers in Oncology hydatidiform mole demographics postmolar gestational trophoblastic neoplasia risk factor pregnancy outcome |
| title | Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China |
| title_full | Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China |
| title_fullStr | Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China |
| title_full_unstemmed | Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China |
| title_short | Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China |
| title_sort | demographics risk factors associated with malignant progression and pregnancy outcomes of hydatidiform mole a retrospective cohort study in shanghai china |
| topic | hydatidiform mole demographics postmolar gestational trophoblastic neoplasia risk factor pregnancy outcome |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1643590/full |
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