Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)
Bone marrow adipose tissue (BMAT) is physiologically linked to bone and energy metabolism, endocrine regulation, hematopoiesis and cancer-related processes. A key challenge in the field is that methods for isolating BMAT or bone marrow adipocytes (BMAds) are variable because there are no widely adop...
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Elsevier
2025-09-01
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| Series: | Bone Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187225000385 |
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| author | Michaela Tencerova Biagio Palmisano Stéphanie Lucas Camille Attané Kaisa K. Ivaska Léa Loisay Yoshiko M. Ikushima Drenka Trivanovic Alessandro Corsi Adriana Roque Hongshuai Li Friederike Behler-Janbeck Jeroen Geurts Mara Riminucci Izabela Podgorski William P. Cawthorn Bram C.J. van der Eerden André J. van Wijnen |
| author_facet | Michaela Tencerova Biagio Palmisano Stéphanie Lucas Camille Attané Kaisa K. Ivaska Léa Loisay Yoshiko M. Ikushima Drenka Trivanovic Alessandro Corsi Adriana Roque Hongshuai Li Friederike Behler-Janbeck Jeroen Geurts Mara Riminucci Izabela Podgorski William P. Cawthorn Bram C.J. van der Eerden André J. van Wijnen |
| author_sort | Michaela Tencerova |
| collection | DOAJ |
| description | Bone marrow adipose tissue (BMAT) is physiologically linked to bone and energy metabolism, endocrine regulation, hematopoiesis and cancer-related processes. A key challenge in the field is that methods for isolating BMAT or bone marrow adipocytes (BMAds) are variable because there are no widely adopted standardized protocols. To generate awareness of this challenge and to establish uniformity in experimental approaches requiring isolation, storage and characterization of BMAT and BMAds, the Biobanking Working Group of the international Bone Marrow Adiposity Society (BMAS) has previously recommended experimental standards. This paper provides an update on this effort and presents current state-of-the-art methods and technical considerations for isolation and characterization of BMAT and BMAds, including currently available high-throughput omics approaches. This review provides a reference point based on the consensus view of BMAS investigators to support studies on biomedical, biological, biochemical and biophysical questions associated with bone marrow adiposity. |
| format | Article |
| id | doaj-art-b5b8abb27cb342a8ae08bc1d937c172a |
| institution | Kabale University |
| issn | 2352-1872 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj-art-b5b8abb27cb342a8ae08bc1d937c172a2025-08-20T03:41:34ZengElsevierBone Reports2352-18722025-09-012610186110.1016/j.bonr.2025.101861Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)Michaela Tencerova0Biagio Palmisano1Stéphanie Lucas2Camille Attané3Kaisa K. Ivaska4Léa Loisay5Yoshiko M. Ikushima6Drenka Trivanovic7Alessandro Corsi8Adriana Roque9Hongshuai Li10Friederike Behler-Janbeck11Jeroen Geurts12Mara Riminucci13Izabela Podgorski14William P. Cawthorn15Bram C.J. van der Eerden16André J. van Wijnen17Laboratory of Molecular Physiology of Bone, Institute of Physiology of the Czech Academy of Sciences, Prague, CzechiaDepartment of Molecular Medicine, Sapienza University, Rome, ItalyMarrow Adiposity and Bone Lab, MABLab-ULR4490, Univ. Littoral Côte d'Opale F-62200 Boulogne-sur-Mer, Univ. Lille F-59000 Lille, CHU Lille, F-59000 Lille, FranceInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS UMR 5089, 205 Route de Narbonne, 31077 Toulouse, FranceInstitute of Biomedicine, University of Turku, Turku, FinlandRheumatology, Department of Musculoskeletal Medicine, University Hospital Lausanne and University of Lausanne (CHUV-UNIL), Lausanne, SwitzerlandDepartment of Medical Science and Innovation, SiRIUS Institute of Medical Research, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai City, Miyagi, 980-8574, JapanGroup for Hematology and Stem Cells, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Molecular Medicine, Sapienza University, Rome, ItalyClinical Hematology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, PortugalDepartment of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, United StatesDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyRheumatology, Department of Musculoskeletal Medicine, University Hospital Lausanne and University of Lausanne (CHUV-UNIL), Lausanne, SwitzerlandDepartment of Molecular Medicine, Sapienza University, Rome, ItalyDepartment of Pharmacology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI, United StatesUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UKLaboratory for Calcium and Bone Metabolism and Erasmus MC Bone Centre, Department of Internal Medicine, Erasmus MC, Erasmus University Medical Center, Rotterdam, the Netherlands; Corresponding author.Department of Biochemistry, Lerner College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, VT, USABone marrow adipose tissue (BMAT) is physiologically linked to bone and energy metabolism, endocrine regulation, hematopoiesis and cancer-related processes. A key challenge in the field is that methods for isolating BMAT or bone marrow adipocytes (BMAds) are variable because there are no widely adopted standardized protocols. To generate awareness of this challenge and to establish uniformity in experimental approaches requiring isolation, storage and characterization of BMAT and BMAds, the Biobanking Working Group of the international Bone Marrow Adiposity Society (BMAS) has previously recommended experimental standards. This paper provides an update on this effort and presents current state-of-the-art methods and technical considerations for isolation and characterization of BMAT and BMAds, including currently available high-throughput omics approaches. This review provides a reference point based on the consensus view of BMAS investigators to support studies on biomedical, biological, biochemical and biophysical questions associated with bone marrow adiposity.http://www.sciencedirect.com/science/article/pii/S2352187225000385 |
| spellingShingle | Michaela Tencerova Biagio Palmisano Stéphanie Lucas Camille Attané Kaisa K. Ivaska Léa Loisay Yoshiko M. Ikushima Drenka Trivanovic Alessandro Corsi Adriana Roque Hongshuai Li Friederike Behler-Janbeck Jeroen Geurts Mara Riminucci Izabela Podgorski William P. Cawthorn Bram C.J. van der Eerden André J. van Wijnen Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS) Bone Reports |
| title | Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS) |
| title_full | Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS) |
| title_fullStr | Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS) |
| title_full_unstemmed | Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS) |
| title_short | Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS) |
| title_sort | experimental analysis of bone marrow adipose tissue and bone marrow adipocytes an update from the bone marrow adiposity society bmas |
| url | http://www.sciencedirect.com/science/article/pii/S2352187225000385 |
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