Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation
Excessive fluoride exposure can lead to health problems, such as fluorosis and neurotoxicity. However, effective therapeutic strategies for neurofluorosis remain elusive due to a limited understanding of the underlying molecular mechanisms. This study aimed to investigate the effects of Tanshinone I...
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Elsevier
2024-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024165802 |
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| author | Qingfeng Shen Shibo Ma Lingbo Li Yingpeng Xia |
| author_facet | Qingfeng Shen Shibo Ma Lingbo Li Yingpeng Xia |
| author_sort | Qingfeng Shen |
| collection | DOAJ |
| description | Excessive fluoride exposure can lead to health problems, such as fluorosis and neurotoxicity. However, effective therapeutic strategies for neurofluorosis remain elusive due to a limited understanding of the underlying molecular mechanisms. This study aimed to investigate the effects of Tanshinone IIA on spinal cord injury induced by high-fluoride exposure. To identify dysregulated genes associated with ferroptosis, we conducted an intersection analysis between differentially expressed genes in fluoride-treated HOS cells (GSE70719) and ferroptosis-related genes from the FerrDb database. A rat model of fluoride-induced spinal cord injury was established, revealing evidence of aberrant molecular and structural changes. Furthermore, the study demonstrated that Tanshinone IIA restored the altered expression of nine ferroptosis-related genes, eight fluorosis-related inflammatory indicators, and the observed structural changes. Overall, these findings suggest that Tanshinone IIA therapeutic potential in the treatment of fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation. |
| format | Article |
| id | doaj-art-b5b575fef00449b7a66d7a287d746fc1 |
| institution | DOAJ |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-b5b575fef00449b7a66d7a287d746fc12025-08-20T02:49:49ZengElsevierHeliyon2405-84402024-12-011023e4054910.1016/j.heliyon.2024.e40549Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammationQingfeng Shen0Shibo Ma1Lingbo Li2Yingpeng Xia3Department of Spine Surgery, Tianjin Union Medical Center, Tianjin, 300121, ChinaDepartment of Spine Surgery, Tianjin Union Medical Center, Tianjin, 300121, ChinaDepartment of Orthopedics, Jingzhou Central Hospital, Jingzhou, 434020, Hubei Province, ChinaDepartment of Spine Surgery, Tianjin Union Medical Center, Tianjin, 300121, China; Corresponding author.Excessive fluoride exposure can lead to health problems, such as fluorosis and neurotoxicity. However, effective therapeutic strategies for neurofluorosis remain elusive due to a limited understanding of the underlying molecular mechanisms. This study aimed to investigate the effects of Tanshinone IIA on spinal cord injury induced by high-fluoride exposure. To identify dysregulated genes associated with ferroptosis, we conducted an intersection analysis between differentially expressed genes in fluoride-treated HOS cells (GSE70719) and ferroptosis-related genes from the FerrDb database. A rat model of fluoride-induced spinal cord injury was established, revealing evidence of aberrant molecular and structural changes. Furthermore, the study demonstrated that Tanshinone IIA restored the altered expression of nine ferroptosis-related genes, eight fluorosis-related inflammatory indicators, and the observed structural changes. Overall, these findings suggest that Tanshinone IIA therapeutic potential in the treatment of fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation.http://www.sciencedirect.com/science/article/pii/S2405844024165802Tanshinone IIASpinal cord injuryFluorideFerroptosis |
| spellingShingle | Qingfeng Shen Shibo Ma Lingbo Li Yingpeng Xia Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation Heliyon Tanshinone IIA Spinal cord injury Fluoride Ferroptosis |
| title | Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation |
| title_full | Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation |
| title_fullStr | Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation |
| title_full_unstemmed | Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation |
| title_short | Tanshinone IIA attenuates fluoride-induced spinal cord injury by inhibiting ferroptosis and inflammation |
| title_sort | tanshinone iia attenuates fluoride induced spinal cord injury by inhibiting ferroptosis and inflammation |
| topic | Tanshinone IIA Spinal cord injury Fluoride Ferroptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024165802 |
| work_keys_str_mv | AT qingfengshen tanshinoneiiaattenuatesfluorideinducedspinalcordinjurybyinhibitingferroptosisandinflammation AT shiboma tanshinoneiiaattenuatesfluorideinducedspinalcordinjurybyinhibitingferroptosisandinflammation AT lingboli tanshinoneiiaattenuatesfluorideinducedspinalcordinjurybyinhibitingferroptosisandinflammation AT yingpengxia tanshinoneiiaattenuatesfluorideinducedspinalcordinjurybyinhibitingferroptosisandinflammation |