Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP Studies
The prevalence of Alzheimer's disease (AD) is predicted to increase rapidly in the coming decade, highlighting the importance of early detection and intervention in patients with AD and mild cognitive impairment (MCI). Recently, remarkable advances have been made in the application of neuroimag...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/719056 |
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| _version_ | 1850159822513635328 |
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| author | Takao Yamasaki Hiroyuki Muranaka Yumiko Kaseda Yasuyo Mimori Shozo Tobimatsu |
| author_facet | Takao Yamasaki Hiroyuki Muranaka Yumiko Kaseda Yasuyo Mimori Shozo Tobimatsu |
| author_sort | Takao Yamasaki |
| collection | DOAJ |
| description | The prevalence of Alzheimer's disease (AD) is predicted to increase rapidly in the coming decade, highlighting the importance of early detection and intervention in patients with AD and mild cognitive impairment (MCI). Recently, remarkable advances have been made in the application of neuroimaging techniques in investigations of AD and MCI. Among the various neuroimaging techniques, functional magnetic resonance imaging (fMRI) has many potential advantages, noninvasively detecting alterations in brain function that may be present very early in the course of AD and MCI. In this paper, we first review task-related and resting-state fMRI studies on AD and MCI. We then present our recent fMRI studies with additional event-related potential (ERP) experiments during a motion perception task in MCI. Our results indicate that fMRI, especially when combined with ERP recording, can be useful for detecting spatiotemporal functional changes in AD and MCI patients. |
| format | Article |
| id | doaj-art-b5b47ccc3b564a73be8e40bb2895177a |
| institution | OA Journals |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-b5b47ccc3b564a73be8e40bb2895177a2025-08-20T02:23:23ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/719056719056Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP StudiesTakao Yamasaki0Hiroyuki Muranaka1Yumiko Kaseda2Yasuyo Mimori3Shozo Tobimatsu4Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanDepartment of Radiology, Hiroshima City General Rehabilitation Center, 1-39-1 Tomo-minami, Asaminami-ku, Hiroshima 731-3168, JapanDepartment of Neurology, Hiroshima City General Rehabilitation Center, 1-39-1 Tomo-minami, Asaminami-ku, Hiroshima 731-3168, JapanDepartment of Physical Therapy, Faculty of Health Sciences, Hiroshima International University, 555-36 Gakuenndai, Kurose, Higashihiroshima, Hiroshima 739-2695, JapanDepartment of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanThe prevalence of Alzheimer's disease (AD) is predicted to increase rapidly in the coming decade, highlighting the importance of early detection and intervention in patients with AD and mild cognitive impairment (MCI). Recently, remarkable advances have been made in the application of neuroimaging techniques in investigations of AD and MCI. Among the various neuroimaging techniques, functional magnetic resonance imaging (fMRI) has many potential advantages, noninvasively detecting alterations in brain function that may be present very early in the course of AD and MCI. In this paper, we first review task-related and resting-state fMRI studies on AD and MCI. We then present our recent fMRI studies with additional event-related potential (ERP) experiments during a motion perception task in MCI. Our results indicate that fMRI, especially when combined with ERP recording, can be useful for detecting spatiotemporal functional changes in AD and MCI patients.http://dx.doi.org/10.1155/2012/719056 |
| spellingShingle | Takao Yamasaki Hiroyuki Muranaka Yumiko Kaseda Yasuyo Mimori Shozo Tobimatsu Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP Studies Neurology Research International |
| title | Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP Studies |
| title_full | Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP Studies |
| title_fullStr | Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP Studies |
| title_full_unstemmed | Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP Studies |
| title_short | Understanding the Pathophysiology of Alzheimer's Disease and Mild Cognitive Impairment: A Mini Review on fMRI and ERP Studies |
| title_sort | understanding the pathophysiology of alzheimer s disease and mild cognitive impairment a mini review on fmri and erp studies |
| url | http://dx.doi.org/10.1155/2012/719056 |
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