Mesenchymal stem cell application in Alzheimer's disease
Alzheimer's disease (AD) is a type of degenerative disease that primarily affects in the central nervous system of elderly or pre-elderly individuals. The symptoms of Alzheimer's disease include memory impairment, aphasia, loss of function, dementia, and impairment of visual spatial abilit...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425001609 |
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| author | Qianying Feng Fengxia Chen Rui Liu Dan Li Huigen Feng Junzheng Yang |
| author_facet | Qianying Feng Fengxia Chen Rui Liu Dan Li Huigen Feng Junzheng Yang |
| author_sort | Qianying Feng |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is a type of degenerative disease that primarily affects in the central nervous system of elderly or pre-elderly individuals. The symptoms of Alzheimer's disease include memory impairment, aphasia, loss of function, dementia, and impairment of visual spatial ability, which in turn affects the physical health of patients. Mesenchymal stem cell therapy is a branch of regenerative medicine that primarily utilizes stem cells or their derivatives to stimulate the body's own healing process and repair damaged, diseased, or injured tissues. Its utilization in the treatment of autoimmune diseases and neurological disorders has been extensively documented. This review summarizes the preclinical and clinical applications of mesenchymal stem cells in AD, their underlying mechanisms and the application limitations of their application and potential solutions. It is hoped that researchers in this field will find it a useful foundation for further study of mesenchymal stem cell therapy. |
| format | Article |
| id | doaj-art-b5b3f8a150284a1b9f93c82c93a844d4 |
| institution | Kabale University |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-b5b3f8a150284a1b9f93c82c93a844d42025-08-20T03:35:40ZengElsevierRegenerative Therapy2352-32042025-12-013043944510.1016/j.reth.2025.07.006Mesenchymal stem cell application in Alzheimer's diseaseQianying Feng0Fengxia Chen1Rui Liu2Dan Li3Huigen Feng4Junzheng Yang5Nursing School, North Henan Medical University, Xinxiang, 453003, ChinaNursing School, North Henan Medical University, Xinxiang, 453003, ChinaNursing School, North Henan Medical University, Xinxiang, 453003, ChinaNursing School, North Henan Medical University, Xinxiang, 453003, ChinaNursing School, North Henan Medical University, Xinxiang, 453003, ChinaNursing School, North Henan Medical University, Xinxiang, 453003, China; Guangdong Nephrotic Drug Engineering Technology Research Center, Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Guangzhou, 510530, China; Corresponding author. Guangdong Nephrotic Drug Engineering Technology Research Center, Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Guangzhou, 510530, China.Alzheimer's disease (AD) is a type of degenerative disease that primarily affects in the central nervous system of elderly or pre-elderly individuals. The symptoms of Alzheimer's disease include memory impairment, aphasia, loss of function, dementia, and impairment of visual spatial ability, which in turn affects the physical health of patients. Mesenchymal stem cell therapy is a branch of regenerative medicine that primarily utilizes stem cells or their derivatives to stimulate the body's own healing process and repair damaged, diseased, or injured tissues. Its utilization in the treatment of autoimmune diseases and neurological disorders has been extensively documented. This review summarizes the preclinical and clinical applications of mesenchymal stem cells in AD, their underlying mechanisms and the application limitations of their application and potential solutions. It is hoped that researchers in this field will find it a useful foundation for further study of mesenchymal stem cell therapy.http://www.sciencedirect.com/science/article/pii/S2352320425001609Mesenchymal stem cellsAlzheimer's diseaseUnderlying mechanismsPreclinical applicationClinical applications |
| spellingShingle | Qianying Feng Fengxia Chen Rui Liu Dan Li Huigen Feng Junzheng Yang Mesenchymal stem cell application in Alzheimer's disease Regenerative Therapy Mesenchymal stem cells Alzheimer's disease Underlying mechanisms Preclinical application Clinical applications |
| title | Mesenchymal stem cell application in Alzheimer's disease |
| title_full | Mesenchymal stem cell application in Alzheimer's disease |
| title_fullStr | Mesenchymal stem cell application in Alzheimer's disease |
| title_full_unstemmed | Mesenchymal stem cell application in Alzheimer's disease |
| title_short | Mesenchymal stem cell application in Alzheimer's disease |
| title_sort | mesenchymal stem cell application in alzheimer s disease |
| topic | Mesenchymal stem cells Alzheimer's disease Underlying mechanisms Preclinical application Clinical applications |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425001609 |
| work_keys_str_mv | AT qianyingfeng mesenchymalstemcellapplicationinalzheimersdisease AT fengxiachen mesenchymalstemcellapplicationinalzheimersdisease AT ruiliu mesenchymalstemcellapplicationinalzheimersdisease AT danli mesenchymalstemcellapplicationinalzheimersdisease AT huigenfeng mesenchymalstemcellapplicationinalzheimersdisease AT junzhengyang mesenchymalstemcellapplicationinalzheimersdisease |