Genetic Counseling in Renal Masses
All urologists have faced patients suffering a renal cancer asking for the occurrence of the disease in their offspring and very often the answer to this question has not been well founded from the scientific point of view, and only in few cases a familial segregation tree is performed. The grate sh...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2008/720840 |
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| _version_ | 1849395946127884288 |
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| author | José Antonio López-Guerrero Zaida García-Casado Antonio Fernández-Serra José Rubio-Briones |
| author_facet | José Antonio López-Guerrero Zaida García-Casado Antonio Fernández-Serra José Rubio-Briones |
| author_sort | José Antonio López-Guerrero |
| collection | DOAJ |
| description | All urologists have faced patients suffering a renal cancer asking for the occurrence of the disease in their offspring and very often the answer to this question has not been well founded from the scientific point of view, and only in few cases a familial segregation tree is performed. The grate shift seen in the detection of small renal masses and renal cancer in the last decades will prompt us to know the indications for familial studies, which and when are necessary, and probably to refer those patients with a suspected familial syndrome to specialized oncological centers where the appropriate molecular and familial studies could be done. Use of molecular genetic testing for early identification of at-risk family members improves diagnostic certainty and would reduce costly screening procedures in at-risk members who have not inherited disease-causing mutations. This review will focus on the molecular bases of familial syndromes associated with small renal masses and the indications of familial studies in at-risk family members. |
| format | Article |
| id | doaj-art-b5aa3ab469d4419da10b79fa48b80b8f |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-b5aa3ab469d4419da10b79fa48b80b8f2025-08-20T03:39:28ZengWileyAdvances in Urology1687-63691687-63772008-01-01200810.1155/2008/720840720840Genetic Counseling in Renal MassesJosé Antonio López-Guerrero0Zaida García-Casado1Antonio Fernández-Serra2José Rubio-Briones3Laboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena 8, 46009 Valencia, SpainLaboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena 8, 46009 Valencia, SpainLaboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena 8, 46009 Valencia, SpainService of Urology, Fundación Instituto Valenciano de Oncología, C/Prof. Beltrán Báguena 8, 46009 Valencia, SpainAll urologists have faced patients suffering a renal cancer asking for the occurrence of the disease in their offspring and very often the answer to this question has not been well founded from the scientific point of view, and only in few cases a familial segregation tree is performed. The grate shift seen in the detection of small renal masses and renal cancer in the last decades will prompt us to know the indications for familial studies, which and when are necessary, and probably to refer those patients with a suspected familial syndrome to specialized oncological centers where the appropriate molecular and familial studies could be done. Use of molecular genetic testing for early identification of at-risk family members improves diagnostic certainty and would reduce costly screening procedures in at-risk members who have not inherited disease-causing mutations. This review will focus on the molecular bases of familial syndromes associated with small renal masses and the indications of familial studies in at-risk family members.http://dx.doi.org/10.1155/2008/720840 |
| spellingShingle | José Antonio López-Guerrero Zaida García-Casado Antonio Fernández-Serra José Rubio-Briones Genetic Counseling in Renal Masses Advances in Urology |
| title | Genetic Counseling in Renal Masses |
| title_full | Genetic Counseling in Renal Masses |
| title_fullStr | Genetic Counseling in Renal Masses |
| title_full_unstemmed | Genetic Counseling in Renal Masses |
| title_short | Genetic Counseling in Renal Masses |
| title_sort | genetic counseling in renal masses |
| url | http://dx.doi.org/10.1155/2008/720840 |
| work_keys_str_mv | AT joseantoniolopezguerrero geneticcounselinginrenalmasses AT zaidagarciacasado geneticcounselinginrenalmasses AT antoniofernandezserra geneticcounselinginrenalmasses AT joserubiobriones geneticcounselinginrenalmasses |