Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice
Ultraviolet radiation (UVR) which could induce skin damage and skin disease is a growing concern due to the increase in global warming. Brown macroalgae Sargassum cristaefolium has been recognized to exhibit UV protective activities. However, the mechanism of its photoprotective activity remains unc...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2020/9769454 |
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| author | Eka Sunarwidhi Prasedya Ni Wayan Riyani Martyasari Angga Susmana Abidin Sonia Ardilla Pebriani Bq Tri Khairina Ilhami Andri Frediansyah Anggit Listyacahyani Sunarwidhi Sri Widyastuti Haji Sunarpi |
| author_facet | Eka Sunarwidhi Prasedya Ni Wayan Riyani Martyasari Angga Susmana Abidin Sonia Ardilla Pebriani Bq Tri Khairina Ilhami Andri Frediansyah Anggit Listyacahyani Sunarwidhi Sri Widyastuti Haji Sunarpi |
| author_sort | Eka Sunarwidhi Prasedya |
| collection | DOAJ |
| description | Ultraviolet radiation (UVR) which could induce skin damage and skin disease is a growing concern due to the increase in global warming. Brown macroalgae Sargassum cristaefolium has been recognized to exhibit UV protective activities. However, the mechanism of its photoprotective activity remains unclear. The purpose of this study is to investigate the potential mechanism of S. cristaefolium’s photoprotective activity against UV radiation. Phytochemical analyses revealed valuable bioactive compounds in SCE, such as fucoxanthin which is widely known as an anti-inflammatory carotenoid. Treatment with SCE before UV-A radiation show reduced levels of wrinkles and desquamation. Interestingly, SCE treatment induces the skin healing process after UV radiation. SCE effectively inhibited proinflammatory TNF-α and IL-6 expression while increasing IL-10 production in the BALB/c mice skin. Current results suggest that SCE potentially protects the skin by attenuation of inflammatory cytokines. In addition, SCE demonstrates promising antibacterial activity (MIC = 1.302 µg/mL) against Staphylococcus aureus. Overall, SCE could be a source of an effective anti-inflammatory agent protecting against UV irradiation-induced skin damages. |
| format | Article |
| id | doaj-art-b5a861c82c7f452aaa3670cf5de7b49f |
| institution | OA Journals |
| issn | 2090-908X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-b5a861c82c7f452aaa3670cf5de7b49f2025-08-20T02:23:23ZengWileyScientifica2090-908X2020-01-01202010.1155/2020/97694549769454Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C MiceEka Sunarwidhi Prasedya0Ni Wayan Riyani Martyasari1Angga Susmana Abidin2Sonia Ardilla Pebriani3Bq Tri Khairina Ilhami4Andri Frediansyah5Anggit Listyacahyani Sunarwidhi6Sri Widyastuti7Haji Sunarpi8Bioscience and Biotechnology Research Centre, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, IndonesiaDepartment of Pharmacy, Udayana University, Jimbaran, Bali, IndonesiaBioscience and Biotechnology Research Centre, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, IndonesiaBioscience and Biotechnology Research Centre, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, IndonesiaBioscience and Biotechnology Research Centre, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, IndonesiaPharmaceutical Institute, University of Tuebingen, Tuebingen, GermanyDepartment of Pharmacy, Medical Faculty, University of Mataram, Mataram, IndonesiaFaculty of Food Technology and Agroindustry, University of Mataram, Mataram, IndonesiaBioscience and Biotechnology Research Centre, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, IndonesiaUltraviolet radiation (UVR) which could induce skin damage and skin disease is a growing concern due to the increase in global warming. Brown macroalgae Sargassum cristaefolium has been recognized to exhibit UV protective activities. However, the mechanism of its photoprotective activity remains unclear. The purpose of this study is to investigate the potential mechanism of S. cristaefolium’s photoprotective activity against UV radiation. Phytochemical analyses revealed valuable bioactive compounds in SCE, such as fucoxanthin which is widely known as an anti-inflammatory carotenoid. Treatment with SCE before UV-A radiation show reduced levels of wrinkles and desquamation. Interestingly, SCE treatment induces the skin healing process after UV radiation. SCE effectively inhibited proinflammatory TNF-α and IL-6 expression while increasing IL-10 production in the BALB/c mice skin. Current results suggest that SCE potentially protects the skin by attenuation of inflammatory cytokines. In addition, SCE demonstrates promising antibacterial activity (MIC = 1.302 µg/mL) against Staphylococcus aureus. Overall, SCE could be a source of an effective anti-inflammatory agent protecting against UV irradiation-induced skin damages.http://dx.doi.org/10.1155/2020/9769454 |
| spellingShingle | Eka Sunarwidhi Prasedya Ni Wayan Riyani Martyasari Angga Susmana Abidin Sonia Ardilla Pebriani Bq Tri Khairina Ilhami Andri Frediansyah Anggit Listyacahyani Sunarwidhi Sri Widyastuti Haji Sunarpi Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice Scientifica |
| title | Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice |
| title_full | Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice |
| title_fullStr | Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice |
| title_full_unstemmed | Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice |
| title_short | Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice |
| title_sort | macroalgae sargassum cristaefolium extract inhibits proinflammatory cytokine expression in balb c mice |
| url | http://dx.doi.org/10.1155/2020/9769454 |
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