Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD)
Objective To look for the prevalence of vitamin D deficiency (VDD) and its association with anti-TPO antibody and thyroid hormones (FT3, FT4, and TSH) levels in newly diagnosed patients with autoimmune thyroid disease (AITD). Methods In this case-control study, new-onset AITD hypothyroidism/hyperthy...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-10-01
|
| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_182_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850199118863925248 |
|---|---|
| author | Nihar R. Sahoo Jeeban Pradhan Deepak K. Dash Pradeep K. Padhi |
| author_facet | Nihar R. Sahoo Jeeban Pradhan Deepak K. Dash Pradeep K. Padhi |
| author_sort | Nihar R. Sahoo |
| collection | DOAJ |
| description | Objective
To look for the prevalence of vitamin D deficiency (VDD) and its association with anti-TPO antibody and thyroid hormones (FT3, FT4, and TSH) levels in newly diagnosed patients with autoimmune thyroid disease (AITD).
Methods
In this case-control study, new-onset AITD hypothyroidism/hyperthyroidism patients (anti-TPO-Ab levels >60 IU/ml) were recruited (n = 50). Fifty age, sex, and BMI-matched euthyroid healthy individuals were taken as controls. Detailed clinical examination and necessary investigations such as serum FT3, FT4, TSH, anti-TPO-Ab, 25 OHD (25 hydroxy vitamin D), and iPTH were measured.
Results
The prevalence of VDD (25 OHD <20 ng/ml) was significantly higher in all AITD cases than that of controls (62% vs. 26%, P = 0.0003). No significant difference was found in the occurrence of VDD between hypothyroid and hyperthyroid AITD patients (69% vs. 50%, P = 0.189). AITD patients with VDD have significantly higher levels of anti-TPO-Ab (702.34 ± 498.54 IU/ml) as compared to vitamin D non deficient AITD subjects (234.64 ± 166.82 IU/ml) (P = 0.0003). Anti-TPO-Ab levels correlated inversely and significantly with 25 OHD levels among all AITD subjects (r = -0.610, P < 0.0001) without any significant correlation with thyroid hormones. Multiple linear regression analysis revealed that only serum 25 OHD had a significant inverse association with anti-TPO-Ab levels (β = -0.323; P = 0.036) but not with thyroid hormones.
Conclusions
Vitamin D deficiency is commonly found in AITD patients. There is a significant negative association between vitamin D levels and anti-TPO-Ab titers suggesting a link between low vitamin D and AITD. |
| format | Article |
| id | doaj-art-b5a69c53be704f16b9ab764f94be18ca |
| institution | OA Journals |
| issn | 2589-8302 2589-8310 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj-art-b5a69c53be704f16b9ab764f94be18ca2025-08-20T02:12:42ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102024-10-0117Suppl 1S193S19810.4103/mjdrdypu.mjdrdypu_182_24Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD)Nihar R. SahooJeeban PradhanDeepak K. DashPradeep K. PadhiObjective To look for the prevalence of vitamin D deficiency (VDD) and its association with anti-TPO antibody and thyroid hormones (FT3, FT4, and TSH) levels in newly diagnosed patients with autoimmune thyroid disease (AITD). Methods In this case-control study, new-onset AITD hypothyroidism/hyperthyroidism patients (anti-TPO-Ab levels >60 IU/ml) were recruited (n = 50). Fifty age, sex, and BMI-matched euthyroid healthy individuals were taken as controls. Detailed clinical examination and necessary investigations such as serum FT3, FT4, TSH, anti-TPO-Ab, 25 OHD (25 hydroxy vitamin D), and iPTH were measured. Results The prevalence of VDD (25 OHD <20 ng/ml) was significantly higher in all AITD cases than that of controls (62% vs. 26%, P = 0.0003). No significant difference was found in the occurrence of VDD between hypothyroid and hyperthyroid AITD patients (69% vs. 50%, P = 0.189). AITD patients with VDD have significantly higher levels of anti-TPO-Ab (702.34 ± 498.54 IU/ml) as compared to vitamin D non deficient AITD subjects (234.64 ± 166.82 IU/ml) (P = 0.0003). Anti-TPO-Ab levels correlated inversely and significantly with 25 OHD levels among all AITD subjects (r = -0.610, P < 0.0001) without any significant correlation with thyroid hormones. Multiple linear regression analysis revealed that only serum 25 OHD had a significant inverse association with anti-TPO-Ab levels (β = -0.323; P = 0.036) but not with thyroid hormones. Conclusions Vitamin D deficiency is commonly found in AITD patients. There is a significant negative association between vitamin D levels and anti-TPO-Ab titers suggesting a link between low vitamin D and AITD.https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_182_24anti-tpo antibodyautoimmune thyroid diseasethyroid hormonesvitamin d deficiency |
| spellingShingle | Nihar R. Sahoo Jeeban Pradhan Deepak K. Dash Pradeep K. Padhi Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD) Medical Journal of Dr. D.Y. Patil Vidyapeeth anti-tpo antibody autoimmune thyroid disease thyroid hormones vitamin d deficiency |
| title | Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD) |
| title_full | Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD) |
| title_fullStr | Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD) |
| title_full_unstemmed | Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD) |
| title_short | Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD) |
| title_sort | prevalence of vitamin d deficiency and its association with thyroid autoimmunity and thyroid hormones in newly diagnosed patients with autoimmune thyroid disease aitd |
| topic | anti-tpo antibody autoimmune thyroid disease thyroid hormones vitamin d deficiency |
| url | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_182_24 |
| work_keys_str_mv | AT niharrsahoo prevalenceofvitaminddeficiencyanditsassociationwiththyroidautoimmunityandthyroidhormonesinnewlydiagnosedpatientswithautoimmunethyroiddiseaseaitd AT jeebanpradhan prevalenceofvitaminddeficiencyanditsassociationwiththyroidautoimmunityandthyroidhormonesinnewlydiagnosedpatientswithautoimmunethyroiddiseaseaitd AT deepakkdash prevalenceofvitaminddeficiencyanditsassociationwiththyroidautoimmunityandthyroidhormonesinnewlydiagnosedpatientswithautoimmunethyroiddiseaseaitd AT pradeepkpadhi prevalenceofvitaminddeficiencyanditsassociationwiththyroidautoimmunityandthyroidhormonesinnewlydiagnosedpatientswithautoimmunethyroiddiseaseaitd |