Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD)
Objective To look for the prevalence of vitamin D deficiency (VDD) and its association with anti-TPO antibody and thyroid hormones (FT3, FT4, and TSH) levels in newly diagnosed patients with autoimmune thyroid disease (AITD). Methods In this case-control study, new-onset AITD hypothyroidism/hyperthy...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_182_24 |
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| Summary: | Objective
To look for the prevalence of vitamin D deficiency (VDD) and its association with anti-TPO antibody and thyroid hormones (FT3, FT4, and TSH) levels in newly diagnosed patients with autoimmune thyroid disease (AITD).
Methods
In this case-control study, new-onset AITD hypothyroidism/hyperthyroidism patients (anti-TPO-Ab levels >60 IU/ml) were recruited (n = 50). Fifty age, sex, and BMI-matched euthyroid healthy individuals were taken as controls. Detailed clinical examination and necessary investigations such as serum FT3, FT4, TSH, anti-TPO-Ab, 25 OHD (25 hydroxy vitamin D), and iPTH were measured.
Results
The prevalence of VDD (25 OHD <20 ng/ml) was significantly higher in all AITD cases than that of controls (62% vs. 26%, P = 0.0003). No significant difference was found in the occurrence of VDD between hypothyroid and hyperthyroid AITD patients (69% vs. 50%, P = 0.189). AITD patients with VDD have significantly higher levels of anti-TPO-Ab (702.34 ± 498.54 IU/ml) as compared to vitamin D non deficient AITD subjects (234.64 ± 166.82 IU/ml) (P = 0.0003). Anti-TPO-Ab levels correlated inversely and significantly with 25 OHD levels among all AITD subjects (r = -0.610, P < 0.0001) without any significant correlation with thyroid hormones. Multiple linear regression analysis revealed that only serum 25 OHD had a significant inverse association with anti-TPO-Ab levels (β = -0.323; P = 0.036) but not with thyroid hormones.
Conclusions
Vitamin D deficiency is commonly found in AITD patients. There is a significant negative association between vitamin D levels and anti-TPO-Ab titers suggesting a link between low vitamin D and AITD. |
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| ISSN: | 2589-8302 2589-8310 |