Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome
Aim. To assess the long-term effectiveness and safety of moxonidine (Physiotens®), as antihypertensive treatment in patients with metabolic syndrome (MS), including women with menopausal MS. Material and methods. The study included 274 patients: 203 women (74 %) and 70 men (26 %). Postmenopausal wom...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2011-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1805 |
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| author | E. V. Tishina V. B. Mychka Yu. V. Zhernakova K. P. Ivanov S. N. Tolstov I. E. Chazova |
| author_facet | E. V. Tishina V. B. Mychka Yu. V. Zhernakova K. P. Ivanov S. N. Tolstov I. E. Chazova |
| author_sort | E. V. Tishina |
| collection | DOAJ |
| description | Aim. To assess the long-term effectiveness and safety of moxonidine (Physiotens®), as antihypertensive treatment in patients with metabolic syndrome (MS), including women with menopausal MS. Material and methods. The study included 274 patients: 203 women (74 %) and 70 men (26 %). Postmenopausal women comprised a separate study subgroup. At baseline and after 24 weeks of moxonidine treatment, all participants underwent anthropometry and the measurement of systolic and diastolic blood pressure (SBP, DBP), lipid and carbohydrate metabolism parameters. Results. Moxonidine therapy was associated with a reduction in SBP and DBP levels. A positive dynamics in the levels of fasting glucose, total cholesterol, low and high-density lipoproteins (LDL, HDL), and triglycerides was observed. The changes in these parameters were similar among postmenopausal women and all study participants. Conclusion. In MS patients, moxonidine improved circadian BP profile, and also demonstrated beneficial effects on carbohydrate and lipid metabolism parameters in women with menopausal MS. |
| format | Article |
| id | doaj-art-b5a66ea5a388420f86063a463ebe15f2 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2011-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-b5a66ea5a388420f86063a463ebe15f22025-08-20T03:43:29Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252011-06-01103404610.15829/1728-8800-2011-3-40-461520Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndromeE. V. Tishina0V. B. Mychka1Yu. V. Zhernakova2K. P. Ivanov3S. N. Tolstov4I. E. Chazova5A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexA.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexA.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexA.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexA.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexA.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexAim. To assess the long-term effectiveness and safety of moxonidine (Physiotens®), as antihypertensive treatment in patients with metabolic syndrome (MS), including women with menopausal MS. Material and methods. The study included 274 patients: 203 women (74 %) and 70 men (26 %). Postmenopausal women comprised a separate study subgroup. At baseline and after 24 weeks of moxonidine treatment, all participants underwent anthropometry and the measurement of systolic and diastolic blood pressure (SBP, DBP), lipid and carbohydrate metabolism parameters. Results. Moxonidine therapy was associated with a reduction in SBP and DBP levels. A positive dynamics in the levels of fasting glucose, total cholesterol, low and high-density lipoproteins (LDL, HDL), and triglycerides was observed. The changes in these parameters were similar among postmenopausal women and all study participants. Conclusion. In MS patients, moxonidine improved circadian BP profile, and also demonstrated beneficial effects on carbohydrate and lipid metabolism parameters in women with menopausal MS.https://cardiovascular.elpub.ru/jour/article/view/1805metabolic syndromearterial hypertensionmenopausemoxonidine |
| spellingShingle | E. V. Tishina V. B. Mychka Yu. V. Zhernakova K. P. Ivanov S. N. Tolstov I. E. Chazova Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome Кардиоваскулярная терапия и профилактика metabolic syndrome arterial hypertension menopause moxonidine |
| title | Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome |
| title_full | Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome |
| title_fullStr | Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome |
| title_full_unstemmed | Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome |
| title_short | Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome |
| title_sort | imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome |
| topic | metabolic syndrome arterial hypertension menopause moxonidine |
| url | https://cardiovascular.elpub.ru/jour/article/view/1805 |
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