Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared Light
Abstract Blood glucose measurement is crucial for diabetes diagnosis and treatment, but invasive sampling methods have drawbacks. Non‐invasive near‐infrared (NIR) spectroscopy‐based optical glucose sensing has gained attention but faces challenges due to the strong absorbance of NIR light by water a...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-03-01
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| Series: | Advanced Sensor Research |
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| Online Access: | https://doi.org/10.1002/adsr.202300160 |
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| author | Mingjie Yang Shanmuga Sundar Dhanabalan Md Rokunuzzaman Robel Litty Varghese Thekkekara Sanje Mahasivam Md Ataur Rahman Sagar Borkhatariya Suvankar Sen Sumeet Walia Sharath Sriram Madhu Bhaskaran |
| author_facet | Mingjie Yang Shanmuga Sundar Dhanabalan Md Rokunuzzaman Robel Litty Varghese Thekkekara Sanje Mahasivam Md Ataur Rahman Sagar Borkhatariya Suvankar Sen Sumeet Walia Sharath Sriram Madhu Bhaskaran |
| author_sort | Mingjie Yang |
| collection | DOAJ |
| description | Abstract Blood glucose measurement is crucial for diabetes diagnosis and treatment, but invasive sampling methods have drawbacks. Non‐invasive near‐infrared (NIR) spectroscopy‐based optical glucose sensing has gained attention but faces challenges due to the strong absorbance of NIR light by water and the need for complex equipment. Here, four distinct glucose fingerprints at specific NIR wavelengths: 1605, 1706, 2145, and 2275 nm are identified. Utilizing a surface‐mounted LED with a spectral range of 1600–1700 nm and focusing on the most prominent peaks at 1605 and 1706 nm, a miniaturized and non‐invasive glucose sensor is developed. The device successfully detects in vitro assays of glucose solutions within the physiological range of 50–400 mg dL−1, attaining a limit of detection as low as 10 mg dL−1. The findings demonstrate the feasibility of NIR spectroscopy‐based glucose sensing and its potential applications in non‐invasive point‐of‐care diagnostics, with the potential for extension to other biomarkers in future. |
| format | Article |
| id | doaj-art-b5a5e43e003c4e18b95476eca7acc939 |
| institution | DOAJ |
| issn | 2751-1219 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj-art-b5a5e43e003c4e18b95476eca7acc9392025-08-20T02:58:00ZengWiley-VCHAdvanced Sensor Research2751-12192025-03-0143n/an/a10.1002/adsr.202300160Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared LightMingjie Yang0Shanmuga Sundar Dhanabalan1Md Rokunuzzaman Robel2Litty Varghese Thekkekara3Sanje Mahasivam4Md Ataur Rahman5Sagar Borkhatariya6Suvankar Sen7Sumeet Walia8Sharath Sriram9Madhu Bhaskaran10Functional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaSir Ian Potter NanoBioSensing Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaFunctional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University Melbourne VIC 3001 AustraliaAbstract Blood glucose measurement is crucial for diabetes diagnosis and treatment, but invasive sampling methods have drawbacks. Non‐invasive near‐infrared (NIR) spectroscopy‐based optical glucose sensing has gained attention but faces challenges due to the strong absorbance of NIR light by water and the need for complex equipment. Here, four distinct glucose fingerprints at specific NIR wavelengths: 1605, 1706, 2145, and 2275 nm are identified. Utilizing a surface‐mounted LED with a spectral range of 1600–1700 nm and focusing on the most prominent peaks at 1605 and 1706 nm, a miniaturized and non‐invasive glucose sensor is developed. The device successfully detects in vitro assays of glucose solutions within the physiological range of 50–400 mg dL−1, attaining a limit of detection as low as 10 mg dL−1. The findings demonstrate the feasibility of NIR spectroscopy‐based glucose sensing and its potential applications in non‐invasive point‐of‐care diagnostics, with the potential for extension to other biomarkers in future.https://doi.org/10.1002/adsr.202300160glucose monitoringnear‐infrared spectroscopyoptical absorbanceoptical glucose detectionwearable device |
| spellingShingle | Mingjie Yang Shanmuga Sundar Dhanabalan Md Rokunuzzaman Robel Litty Varghese Thekkekara Sanje Mahasivam Md Ataur Rahman Sagar Borkhatariya Suvankar Sen Sumeet Walia Sharath Sriram Madhu Bhaskaran Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared Light Advanced Sensor Research glucose monitoring near‐infrared spectroscopy optical absorbance optical glucose detection wearable device |
| title | Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared Light |
| title_full | Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared Light |
| title_fullStr | Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared Light |
| title_full_unstemmed | Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared Light |
| title_short | Miniaturized Optical Glucose Sensor Using 1600–1700 nm Near‐Infrared Light |
| title_sort | miniaturized optical glucose sensor using 1600 1700 nm near infrared light |
| topic | glucose monitoring near‐infrared spectroscopy optical absorbance optical glucose detection wearable device |
| url | https://doi.org/10.1002/adsr.202300160 |
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