The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35–70, affected by moderate-to-severe p...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/8516527 |
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| author | Gita Faghihi Saghi Fatemi-Tabaei Bahareh Abtahi-Naeini Amir Hossein Siadat Giti Sadeghian Mohammad Ali Nilforoushzadeh Hamed Mohamadian-shoeili |
| author_facet | Gita Faghihi Saghi Fatemi-Tabaei Bahareh Abtahi-Naeini Amir Hossein Siadat Giti Sadeghian Mohammad Ali Nilforoushzadeh Hamed Mohamadian-shoeili |
| author_sort | Gita Faghihi |
| collection | DOAJ |
| description | Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35–70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5% retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale. Patients were assessed at 2 weeks and 1, 2, and 6 months after treatment initiation. Results. The mean ± SD age of participants was 49.55±11.61 years, and the majorities (73.3%) were female. Between 1 month and 2 months, participants reported slight but statistically significant improvements for all parameters (P<0.001). In terms of adverse effects, there were statistically significant differences reported between the 5% retinoic acid peel groups and the control group (P<0.001). The majority of adverse effects reported in the study were described as mild and transient. Conclusion. This study demonstrated that 5% retinoic acid peel cream combined with microdermabrasion was safe and effective in the treatment of photoaging in the Iranian population. This trial is registered with IRCT2015121112782N8. |
| format | Article |
| id | doaj-art-b5a59160bf5145b0a765c0786be0baec |
| institution | DOAJ |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-b5a59160bf5145b0a765c0786be0baec2025-08-20T03:20:55ZengWileyDermatology Research and Practice1687-61051687-61132017-01-01201710.1155/2017/85165278516527The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialGita Faghihi0Saghi Fatemi-Tabaei1Bahareh Abtahi-Naeini2Amir Hossein Siadat3Giti Sadeghian4Mohammad Ali Nilforoushzadeh5Hamed Mohamadian-shoeili6Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, IranSkin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, IranCancer Research Center, Semnan University of Medical Sciences, Semnan, IranSkin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, IranSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Kermanshah University of Medical Science, Imam Reza Hospital, Kermanshah, IranBackground. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35–70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5% retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale. Patients were assessed at 2 weeks and 1, 2, and 6 months after treatment initiation. Results. The mean ± SD age of participants was 49.55±11.61 years, and the majorities (73.3%) were female. Between 1 month and 2 months, participants reported slight but statistically significant improvements for all parameters (P<0.001). In terms of adverse effects, there were statistically significant differences reported between the 5% retinoic acid peel groups and the control group (P<0.001). The majority of adverse effects reported in the study were described as mild and transient. Conclusion. This study demonstrated that 5% retinoic acid peel cream combined with microdermabrasion was safe and effective in the treatment of photoaging in the Iranian population. This trial is registered with IRCT2015121112782N8.http://dx.doi.org/10.1155/2017/8516527 |
| spellingShingle | Gita Faghihi Saghi Fatemi-Tabaei Bahareh Abtahi-Naeini Amir Hossein Siadat Giti Sadeghian Mohammad Ali Nilforoushzadeh Hamed Mohamadian-shoeili The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Dermatology Research and Practice |
| title | The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full | The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_fullStr | The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full_unstemmed | The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_short | The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_sort | effectiveness of a 5 retinoic acid peel combined with microdermabrasion for facial photoaging a randomized double blind placebo controlled clinical trial |
| url | http://dx.doi.org/10.1155/2017/8516527 |
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