Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes
LY 255283 [(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-)1H-tetrazol-5-yl)-heptyloxy) phenyl)ethanone], a specific leukotriene B4 (LTB4) receptor antagonist, inhibited the production of LTB4 in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187....
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000572 |
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| _version_ | 1832560756447510528 |
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| author | M. Ugur M. Melli |
| author_facet | M. Ugur M. Melli |
| author_sort | M. Ugur |
| collection | DOAJ |
| description | LY 255283 [(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-)1H-tetrazol-5-yl)-heptyloxy) phenyl)ethanone], a specific leukotriene B4 (LTB4) receptor antagonist, inhibited the production of LTB4 in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187. In human monocytes activated by ionophore it inhibited also the production of thromboxane B2 (TXB2). The effect of LY 255283 on 5-lipoxygenase (5-LO) and LTA4 hydrolase activities which catalyse the production of LTB4 and LTA4 has not been studied yet. It is thought that LY 255283 may inhibit the production of LTB4 and TXA2 by antagonising the effect of ionophore-induced LTB4 on 5-lipoxygenase and cyclooxygenase in human peripheral blood PMNL and monocytes. |
| format | Article |
| id | doaj-art-b5a481171b7049cebaaafeb02851d644 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b5a481171b7049cebaaafeb02851d6442025-02-03T01:26:46ZengWileyMediators of Inflammation0962-93511466-18611993-01-012640740910.1155/S0962935193000572Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytesM. Ugur0M. Melli1Department of Pharmacology, Medical Faculty of Ankara University, Sihhiye, Ankara 06100, TurkeyDepartment of Pharmacology, Medical Faculty of Ankara University, Sihhiye, Ankara 06100, TurkeyLY 255283 [(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-)1H-tetrazol-5-yl)-heptyloxy) phenyl)ethanone], a specific leukotriene B4 (LTB4) receptor antagonist, inhibited the production of LTB4 in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187. In human monocytes activated by ionophore it inhibited also the production of thromboxane B2 (TXB2). The effect of LY 255283 on 5-lipoxygenase (5-LO) and LTA4 hydrolase activities which catalyse the production of LTB4 and LTA4 has not been studied yet. It is thought that LY 255283 may inhibit the production of LTB4 and TXA2 by antagonising the effect of ionophore-induced LTB4 on 5-lipoxygenase and cyclooxygenase in human peripheral blood PMNL and monocytes.http://dx.doi.org/10.1155/S0962935193000572 |
| spellingShingle | M. Ugur M. Melli Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes Mediators of Inflammation |
| title | Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes |
| title_full | Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes |
| title_fullStr | Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes |
| title_full_unstemmed | Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes |
| title_short | Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes |
| title_sort | inhibitory effect of ly 255283 on the synthesis of leukotriene b4 and thromboxane a2 in human peripheral blood polymorphonuclear leukocytes and monocytes |
| url | http://dx.doi.org/10.1155/S0962935193000572 |
| work_keys_str_mv | AT mugur inhibitoryeffectofly255283onthesynthesisofleukotrieneb4andthromboxanea2inhumanperipheralbloodpolymorphonuclearleukocytesandmonocytes AT mmelli inhibitoryeffectofly255283onthesynthesisofleukotrieneb4andthromboxanea2inhumanperipheralbloodpolymorphonuclearleukocytesandmonocytes |