A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage
Objectives: To determine the effectiveness of intrauterine misoprostol along with oxytocin versus oxytocin monotherapy for the prevention of primary postpartum haemorrhage. Method: The quasi-randomised controlled trial took place at the Akbar Niazi Teaching Hospital, Islamabad, Pakistan, from Feb...
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Pakistan Medical Association
2025-02-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/11080 |
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| author | Afnan Rizwan Muhammad Hassaan Farooq Uzma Nayyer Asma Irfan Mahwish Farooq Maryam Siddique |
| author_facet | Afnan Rizwan Muhammad Hassaan Farooq Uzma Nayyer Asma Irfan Mahwish Farooq Maryam Siddique |
| author_sort | Afnan Rizwan |
| collection | DOAJ |
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Objectives: To determine the effectiveness of intrauterine misoprostol along with oxytocin versus oxytocin monotherapy for the prevention of primary postpartum haemorrhage.
Method: The quasi-randomised controlled trial took place at the Akbar Niazi Teaching Hospital, Islamabad, Pakistan, from February to August 2021, and comprised women who underwent lower segment caesarean section and at full-term pregnancy who had risk factors for experiencing postpartum haemorrhage. The subjects were randomised into experimental group A and control group B. Group A subjects received both misoprostol and oxytocin, while those in group B received oxytocin only. Data was analysed using SPSS 26.
Results: Of the 120 subjects, 60(50%) were in group A with mean age 28.72±5.82 years and mean gestational age 38.02±1.1 weeks. The remaining 60(50%) subjects were in group B with mean age 29.47±4.72 years and mean gestational age 37.50±1.5 weeks. Group A subjects had fewer changes in haemoglobin levels post-operation than those in group B (p<0.05). The number of operative towels used, contractility time of the uterus, and need for other drugs to control haemorrhage were significantly different in group A compared to group B.
Conclusion: Misoprostol along with oxytocin was found to be more effective in reducing blood loss in patients with postpartum haemorrhage.
Key Words: Postpartum haemorrhage, Misoprostol, Oxytocin, Postoperative blood loss.
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| format | Article |
| id | doaj-art-b59e9598f2694daf9607d437268cc828 |
| institution | DOAJ |
| issn | 0030-9982 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-b59e9598f2694daf9607d437268cc8282025-08-20T02:41:24ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822025-02-01750310.47391/JPMA.11080A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhageAfnan Rizwan0Muhammad Hassaan Farooq1Uzma Nayyer2Asma Irfan3Mahwish Farooq4Maryam Siddique5Department of Gynaecology, Dr. Akbar Niazi Teaching, Hospital, Islamabad, Pakistan4th Year MBBS Student, Islamabad Medical and Dental College, Islamabad, PakistanDepartment of Gynaecology, Dr. Akbar Niazi Teaching, Hospital, Islamabad, PakistanDepartment of Physiology, Islamabad Medical and Dental College, Islamabad, PakistanDepartment of Gynaecology, City Hospital, Gujrat, Pakistan4th Year MBBS Student, Islamabad Medical and Dental College, Islamabad, Pakistan Objectives: To determine the effectiveness of intrauterine misoprostol along with oxytocin versus oxytocin monotherapy for the prevention of primary postpartum haemorrhage. Method: The quasi-randomised controlled trial took place at the Akbar Niazi Teaching Hospital, Islamabad, Pakistan, from February to August 2021, and comprised women who underwent lower segment caesarean section and at full-term pregnancy who had risk factors for experiencing postpartum haemorrhage. The subjects were randomised into experimental group A and control group B. Group A subjects received both misoprostol and oxytocin, while those in group B received oxytocin only. Data was analysed using SPSS 26. Results: Of the 120 subjects, 60(50%) were in group A with mean age 28.72±5.82 years and mean gestational age 38.02±1.1 weeks. The remaining 60(50%) subjects were in group B with mean age 29.47±4.72 years and mean gestational age 37.50±1.5 weeks. Group A subjects had fewer changes in haemoglobin levels post-operation than those in group B (p<0.05). The number of operative towels used, contractility time of the uterus, and need for other drugs to control haemorrhage were significantly different in group A compared to group B. Conclusion: Misoprostol along with oxytocin was found to be more effective in reducing blood loss in patients with postpartum haemorrhage. Key Words: Postpartum haemorrhage, Misoprostol, Oxytocin, Postoperative blood loss. https://jpma.org.pk/index.php/public_html/article/view/11080Postpartum haemorrhageMisoprostolOxytocinPostoperative blood loss |
| spellingShingle | Afnan Rizwan Muhammad Hassaan Farooq Uzma Nayyer Asma Irfan Mahwish Farooq Maryam Siddique A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage Journal of the Pakistan Medical Association Postpartum haemorrhage Misoprostol Oxytocin Postoperative blood loss |
| title | A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage |
| title_full | A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage |
| title_fullStr | A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage |
| title_full_unstemmed | A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage |
| title_short | A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage |
| title_sort | comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage |
| topic | Postpartum haemorrhage Misoprostol Oxytocin Postoperative blood loss |
| url | https://jpma.org.pk/index.php/public_html/article/view/11080 |
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