Formulation and optimisation of bedaquiline nanoemulsions for the potential treatment of multi drug resistant tuberculosis in paediatrics using quality by design

Formulation and optimisation of bedaquiline nanoemulsions for the potential treatment of multi drug resistant tuberculosis in paediatrics using quality by design

Abstract Bedaquiline is a drug used for the treatment of multidrug-resistant TB in adults and children that is currently only commercially available in tablet form. The present study was aimed at preparing nanoemulsion (NE) of BDQ using natural vegetable oils to deliver BDQ. The optimisation of surf...

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Bibliographic Details
Main Authors: Taiwo Oreoluwa Ajayi, Madan Sai Poka, Bwalya Angel Witika
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Nanoemulsions
Bedaquiline
Drug Release
Droplet size
Zeta potential
Quality by Design
Online Access:https://doi.org/10.1038/s41598-024-83408-1
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