Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients
Abstract Impulsive‐compulsive behaviors (ICB) are common non‐motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision‐making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.52249 |
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| author | Fabio Taddeini Erica Ordali Alessandra Govoni Francesca Piattellini Simone Valente Luca Caremani Alberto A Vergani Ahmet Kaymak Aldo Rustichini Eleonora Russo Chiara Rapallini Silvia Ramat Alberto Mazzoni |
| author_facet | Fabio Taddeini Erica Ordali Alessandra Govoni Francesca Piattellini Simone Valente Luca Caremani Alberto A Vergani Ahmet Kaymak Aldo Rustichini Eleonora Russo Chiara Rapallini Silvia Ramat Alberto Mazzoni |
| author_sort | Fabio Taddeini |
| collection | DOAJ |
| description | Abstract Impulsive‐compulsive behaviors (ICB) are common non‐motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision‐making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls (HC). Participants performed a risk‐based decision‐making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk‐averting strategy. In DD ON, ICB+ patients (but not ICB− nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision‐making. |
| format | Article |
| id | doaj-art-b5992fbf55534667afb3f87334e76c62 |
| institution | DOAJ |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-b5992fbf55534667afb3f87334e76c622025-08-20T03:02:38ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-03-0112363163610.1002/acn3.52249Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patientsFabio Taddeini0Erica Ordali1Alessandra Govoni2Francesca Piattellini3Simone Valente4Luca Caremani5Alberto A Vergani6Ahmet Kaymak7Aldo Rustichini8Eleonora Russo9Chiara Rapallini10Silvia Ramat11Alberto Mazzoni12The Biorobotics Institute Scuola Superiore Sant'Anna Pisa ItalyDepartment of Economics and Management University of Florence Florence ItalyParkinson Unit, Department of NeuroMuscular‐Skeletal and Sensorial Organs Azienda Ospedaliero Universitaria Careggi Florence ItalyParkinson Unit, Department of NeuroMuscular‐Skeletal and Sensorial Organs Azienda Ospedaliero Universitaria Careggi Florence ItalyParkinson Unit, Department of NeuroMuscular‐Skeletal and Sensorial Organs Azienda Ospedaliero Universitaria Careggi Florence ItalyParkinson Unit, Department of NeuroMuscular‐Skeletal and Sensorial Organs Azienda Ospedaliero Universitaria Careggi Florence ItalyThe Biorobotics Institute Scuola Superiore Sant'Anna Pisa ItalyThe Biorobotics Institute Scuola Superiore Sant'Anna Pisa ItalyUniversity of Minnesota Hanson Hall Minneapolis USAThe Biorobotics Institute Scuola Superiore Sant'Anna Pisa ItalyDepartment of Economics and Management University of Florence Florence ItalyParkinson Unit, Department of NeuroMuscular‐Skeletal and Sensorial Organs Azienda Ospedaliero Universitaria Careggi Florence ItalyThe Biorobotics Institute Scuola Superiore Sant'Anna Pisa ItalyAbstract Impulsive‐compulsive behaviors (ICB) are common non‐motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision‐making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls (HC). Participants performed a risk‐based decision‐making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk‐averting strategy. In DD ON, ICB+ patients (but not ICB− nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision‐making.https://doi.org/10.1002/acn3.52249 |
| spellingShingle | Fabio Taddeini Erica Ordali Alessandra Govoni Francesca Piattellini Simone Valente Luca Caremani Alberto A Vergani Ahmet Kaymak Aldo Rustichini Eleonora Russo Chiara Rapallini Silvia Ramat Alberto Mazzoni Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients Annals of Clinical and Translational Neurology |
| title | Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients |
| title_full | Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients |
| title_fullStr | Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients |
| title_full_unstemmed | Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients |
| title_short | Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients |
| title_sort | dopaminergic therapy disrupts decision making in impulsive compulsive parkinsonian patients |
| url | https://doi.org/10.1002/acn3.52249 |
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