Unveiling the role of BON domain-containing proteins in antibiotic resistance
The alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access. While diffusion porins are well-studied, the role of BON domain-containing proteins (BDCPs) in resistance remains unexplored. We analyze protein dat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1518045/full |
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| _version_ | 1841556670583406592 |
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| author | Shengwei Sun Jinju Chen |
| author_facet | Shengwei Sun Jinju Chen |
| author_sort | Shengwei Sun |
| collection | DOAJ |
| description | The alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access. While diffusion porins are well-studied, the role of BON domain-containing proteins (BDCPs) in resistance remains unexplored. We analyze protein databases, revealing widespread BDCP distribution across environmental bacteria. We further describe their conserved core domain structure, a key for understanding antibiotic transport. Elucidating the genetic and biochemical basis of BDCPs offers a novel target to combat antibiotic resistance and restore bacterial susceptibility to antibiotics. |
| format | Article |
| id | doaj-art-b59004d2a2a5474b927913293a2c7854 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-b59004d2a2a5474b927913293a2c78542025-01-07T06:46:41ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011510.3389/fmicb.2024.15180451518045Unveiling the role of BON domain-containing proteins in antibiotic resistanceShengwei Sun0Jinju Chen1Department of Fibre and Polymer Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, SwedenDepartment of Materials, Loughborough University, Loughborough, United KingdomThe alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access. While diffusion porins are well-studied, the role of BON domain-containing proteins (BDCPs) in resistance remains unexplored. We analyze protein databases, revealing widespread BDCP distribution across environmental bacteria. We further describe their conserved core domain structure, a key for understanding antibiotic transport. Elucidating the genetic and biochemical basis of BDCPs offers a novel target to combat antibiotic resistance and restore bacterial susceptibility to antibiotics.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1518045/fullcell envelopeBON domain-containing proteinantibiotic resistancestructure and functionpathogens |
| spellingShingle | Shengwei Sun Jinju Chen Unveiling the role of BON domain-containing proteins in antibiotic resistance Frontiers in Microbiology cell envelope BON domain-containing protein antibiotic resistance structure and function pathogens |
| title | Unveiling the role of BON domain-containing proteins in antibiotic resistance |
| title_full | Unveiling the role of BON domain-containing proteins in antibiotic resistance |
| title_fullStr | Unveiling the role of BON domain-containing proteins in antibiotic resistance |
| title_full_unstemmed | Unveiling the role of BON domain-containing proteins in antibiotic resistance |
| title_short | Unveiling the role of BON domain-containing proteins in antibiotic resistance |
| title_sort | unveiling the role of bon domain containing proteins in antibiotic resistance |
| topic | cell envelope BON domain-containing protein antibiotic resistance structure and function pathogens |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1518045/full |
| work_keys_str_mv | AT shengweisun unveilingtheroleofbondomaincontainingproteinsinantibioticresistance AT jinjuchen unveilingtheroleofbondomaincontainingproteinsinantibioticresistance |