Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life Improvement
Introduction: An inexplicable burning sensation in the oral mucosa is the hallmark of Burning Mouth Syndrome (BMS), a chronic illness that is often connected to inflammatory and neuropathic processes. Materials and Methods: A double-blind, randomized, placebo-controlled study including 120 individua...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_339_25 |
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| author | Rahul Srivastava Saquib Khan Dhirendra Kumar Singh Sangita Nath Dharitri Bharali Hiroj Bagde |
| author_facet | Rahul Srivastava Saquib Khan Dhirendra Kumar Singh Sangita Nath Dharitri Bharali Hiroj Bagde |
| author_sort | Rahul Srivastava |
| collection | DOAJ |
| description | Introduction:
An inexplicable burning sensation in the oral mucosa is the hallmark of Burning Mouth Syndrome (BMS), a chronic illness that is often connected to inflammatory and neuropathic processes.
Materials and Methods:
A double-blind, randomized, placebo-controlled study including 120 individuals with a BMS diagnosis was carried out. Over the course of 12 weeks, participants were randomized to receive either a placebo or 2 grams of omega-3 fatty acids (EPA and DHA) daily. The Visual Analog Scale (VAS) was used to quantify the change in pain intensity, which was the main result. Secondary outcomes were patient-reported symptom alleviation and quality of life as measured by the Oral Health Impact Profile (OHIP-14).
Results:
In total, 110 out of the 120 individuals finished the study. When compared to the placebo group, the omega-3 group’s VAS pain ratings significantly decreased (mean change: -3.4 vs. -1.2, P < 0.001). Additionally, the omega-3 group saw considerably higher improvements in quality of life, with a mean decrease in OHIP-14 ratings of -8.7 points compared to -3.1 in the placebo group (P < 0.001). In the omega-3 group, most patients experienced moderate to total symptom alleviation (82% vs. 45%, P < 0.001). The omega-3 group had higher gastrointestinal pain, although adverse effects were generally moderate.
Conclusion:
Omega-3 fatty acid supplementation significantly reduces pain and improves quality of life in patients with BMS, providing a safe and effective alternative to conventional treatments. |
| format | Article |
| id | doaj-art-b5833351ba5a4e848310cad8d7152fef |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-b5833351ba5a4e848310cad8d7152fef2025-08-20T03:31:38ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1362S136410.4103/jpbs.jpbs_339_25Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life ImprovementRahul SrivastavaSaquib KhanDhirendra Kumar SinghSangita NathDharitri BharaliHiroj BagdeIntroduction: An inexplicable burning sensation in the oral mucosa is the hallmark of Burning Mouth Syndrome (BMS), a chronic illness that is often connected to inflammatory and neuropathic processes. Materials and Methods: A double-blind, randomized, placebo-controlled study including 120 individuals with a BMS diagnosis was carried out. Over the course of 12 weeks, participants were randomized to receive either a placebo or 2 grams of omega-3 fatty acids (EPA and DHA) daily. The Visual Analog Scale (VAS) was used to quantify the change in pain intensity, which was the main result. Secondary outcomes were patient-reported symptom alleviation and quality of life as measured by the Oral Health Impact Profile (OHIP-14). Results: In total, 110 out of the 120 individuals finished the study. When compared to the placebo group, the omega-3 group’s VAS pain ratings significantly decreased (mean change: -3.4 vs. -1.2, P < 0.001). Additionally, the omega-3 group saw considerably higher improvements in quality of life, with a mean decrease in OHIP-14 ratings of -8.7 points compared to -3.1 in the placebo group (P < 0.001). In the omega-3 group, most patients experienced moderate to total symptom alleviation (82% vs. 45%, P < 0.001). The omega-3 group had higher gastrointestinal pain, although adverse effects were generally moderate. Conclusion: Omega-3 fatty acid supplementation significantly reduces pain and improves quality of life in patients with BMS, providing a safe and effective alternative to conventional treatments.https://journals.lww.com/10.4103/jpbs.jpbs_339_25burning mouth syndrome (bms)docosahexaenoic acid (dha)eicosapentaenoic acid (epa)neuropathic painomega-3 fatty acids |
| spellingShingle | Rahul Srivastava Saquib Khan Dhirendra Kumar Singh Sangita Nath Dharitri Bharali Hiroj Bagde Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life Improvement Journal of Pharmacy and Bioallied Sciences burning mouth syndrome (bms) docosahexaenoic acid (dha) eicosapentaenoic acid (epa) neuropathic pain omega-3 fatty acids |
| title | Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life Improvement |
| title_full | Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life Improvement |
| title_fullStr | Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life Improvement |
| title_full_unstemmed | Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life Improvement |
| title_short | Managing Burning Mouth Syndrome with Omega-3 Fatty Acids: A Clinical Trial of Pain Relief and Quality of Life Improvement |
| title_sort | managing burning mouth syndrome with omega 3 fatty acids a clinical trial of pain relief and quality of life improvement |
| topic | burning mouth syndrome (bms) docosahexaenoic acid (dha) eicosapentaenoic acid (epa) neuropathic pain omega-3 fatty acids |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_339_25 |
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