Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients
We hypothesized that the individual hematological response to chemo/ radiotherapy may be used as a parameter to assess the degree of myeloablation and probability of transplant-related events. This study included 58 pediatric patients who underwent allogeneic hematopoietic stem cell transplan...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2014-02-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1311 |
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| author | Barış Kuşkonmaz S Songül Yalçın Dilek Azkur Selin Aytaç-Eyüpoğlu Pınar Özdemir Mualla Çetin Duygu Uçkan-Çetinkaya |
| author_facet | Barış Kuşkonmaz S Songül Yalçın Dilek Azkur Selin Aytaç-Eyüpoğlu Pınar Özdemir Mualla Çetin Duygu Uçkan-Çetinkaya |
| author_sort | Barış Kuşkonmaz |
| collection | DOAJ |
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We hypothesized that the individual hematological response to chemo/ radiotherapy may be used as a parameter to assess the degree of myeloablation and probability of transplant-related events. This study included 58 pediatric patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT). White blood cell (WBC) ratio (pre-conditioning WBC: day 0 WBC), day 0 WBC count, and WBC nadir day were used as potential indicators of myeloablation. The association between WBC kinetics and clinical result of HSCT was investigated. There was a positive correlation between WBC ratio and the date of engraftment. A positive correlation was noted between day 0 WBC count and engraftment day. There was a negative correlation between WBC nadir day and engraftment day. WBC nadir day was lower in patients with acute graft-versus-host disease (GVHD) than in cases without acute GVHD. Among patients who had fever during the conditioning regimen, the WBC ratio was higher, day 0 WBC count was lower, and WBC nadir day was lower in patients who developed >5 days of fever between day 0 and day +30. The present preliminary study suggests that WBC kinetics may be used as a measure of initial hematological response to the conditioning regimen and perhaps in determining the degree of myeloablation.
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| format | Article |
| id | doaj-art-b57fd3f0529c4fb4b24afddbd95dc7cb |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2014-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-b57fd3f0529c4fb4b24afddbd95dc7cb2025-08-20T02:01:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212014-02-01561Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patientsBarış Kuşkonmaz0S Songül YalçınDilek AzkurSelin Aytaç-EyüpoğluPınar ÖzdemirMualla ÇetinDuygu Uçkan-ÇetinkayaDivisions of 1Pediatric Bone Marrow Transplantation, Hacettepe University Faculty of Medicine, Ankara, Turkey. duckan@hacettepe.edu.tr. We hypothesized that the individual hematological response to chemo/ radiotherapy may be used as a parameter to assess the degree of myeloablation and probability of transplant-related events. This study included 58 pediatric patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT). White blood cell (WBC) ratio (pre-conditioning WBC: day 0 WBC), day 0 WBC count, and WBC nadir day were used as potential indicators of myeloablation. The association between WBC kinetics and clinical result of HSCT was investigated. There was a positive correlation between WBC ratio and the date of engraftment. A positive correlation was noted between day 0 WBC count and engraftment day. There was a negative correlation between WBC nadir day and engraftment day. WBC nadir day was lower in patients with acute graft-versus-host disease (GVHD) than in cases without acute GVHD. Among patients who had fever during the conditioning regimen, the WBC ratio was higher, day 0 WBC count was lower, and WBC nadir day was lower in patients who developed >5 days of fever between day 0 and day +30. The present preliminary study suggests that WBC kinetics may be used as a measure of initial hematological response to the conditioning regimen and perhaps in determining the degree of myeloablation. https://turkjpediatr.org/article/view/1311 |
| spellingShingle | Barış Kuşkonmaz S Songül Yalçın Dilek Azkur Selin Aytaç-Eyüpoğlu Pınar Özdemir Mualla Çetin Duygu Uçkan-Çetinkaya Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients The Turkish Journal of Pediatrics |
| title | Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients |
| title_full | Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients |
| title_fullStr | Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients |
| title_full_unstemmed | Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients |
| title_short | Initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients |
| title_sort | initial white blood cell kinetics for assessment of individual response to the conditioning regimen in pediatric hematopoietic stem cell transplantation patients |
| url | https://turkjpediatr.org/article/view/1311 |
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