Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of bla KPC-3 and PBP3 mutations

Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of bla KPC-3 and PBP3 mutations

Abstract The emergence of carbapenemase-producing Enterobacterales represents a significant clinical challenge. Resistance mechanisms involve carbapenemase production, porin and efflux pump alterations, penicillin-binding protein (PBP) modifications, and biofilm formation. This study characterizes a...

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Main Authors: Simone Giuliano, Valeria Fox, Sara Ferin, Luca Martini, Jacopo Angelini, Michela Bulfoni, Beatrice Krpan, Nicolò Gualandi, Chiara Moreal, Carlo Federico Perno, Paola Bernaschi, Ciro Di Gennaro, Celeste Arcamone, Sara Turco, Maria Cristina Stanziola, Rosa Manzi, Francesco Curcio, Corrado Pipan, Carlo Tascini
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Escherichia coli
Klebsiella pneumoniae
KPC
PBP3
Avibactam
Conjugation
Online Access:https://doi.org/10.1038/s41598-025-07624-z
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